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You need to add one carbon, the easiest source of this is as CN-.
Three steps.
Reduce phenylacetic acid to 2-phenylethanol (borane.THF is a good way)
Form the tosylate of the alcohol (TsCl, pyridine)
Treat the tosylate with NaCN in DMSO reference here.
More
VOTE
2026-07-05
You need to add one carbon, the easiest source of this is as CN-.
Three steps.
Reduce phenylacetic acid to 2-phenylethanol (borane.THF is a good way)
Form the tosylate of the alcohol (TsCl, pyridine)
Treat the tosylate with NaCN in DMSO reference here.
You need to add one carbon, the easiest source of this is as CN-.
Three steps.
Reduce phenylacetic acid to 2-phenylethanol (borane.THF is a good way)
Form the tosylate of the alcohol (TsCl, pyridine)
Treat the tosylate with NaCN in DMSO reference here.
More
VOTE