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How to purify the acid acyl chloride and ester?
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Martin Reyto
How to purify the acid acyl chloride and ester?
Excessive acid chloride or acid chloride hydrolyzate can be dissolved with aqueous sodium bicarbonate solution
ester can be dissolved with dichloromethane, or cyclohexane, so that the organic phase is separated from the aqueous phase [123That is, it is necessary to wash the organic phase with aqueous solution of sodium hydrogencarbonate
base is not too strong, dissolved in the ester hydrolysis
Excessive acid chloride or acid chloride hydrolyzate can be dissolved with aqueous sodium bicarbonate solution
ester can be dissolved with dichloromethane, or cyclohexane, so that the organic phase is separated from the aqueous phase [123That is, it is necessary to wash the organic phase with aqueous solution of sodium hydrogencarbonate
base is not too strong, dissolved in the ester hydrolysis
Determine if the reaction is complete. The acid chloride is reacted with an ester to form another acid chloride and ester. Purified, a lot of benzene ring should be solid, and the product is not high, and the reaction generated is removed by the reaction system.Then separated by distillation. High boiling point, find a suitable solvent for crystallization or recrystallization.
Determine if the reaction is complete. The acid chloride is reacted with an ester to form another acid chloride and ester. Purified, a lot of benzene ring should be solid, and the product is not high, and the reaction generated is removed by the reaction system.Then separated by distillation. High boiling point, find a suitable solvent for crystallization or recrystallization.
ester can be dissolved with dichloromethane, or cyclohexane, so that the organic phase is separated from the aqueous phase
[123That is, it is necessary to wash the organic phase with aqueous solution of sodium hydrogencarbonate
base is not too strong, dissolved in the ester hydrolysis
ester can be dissolved with dichloromethane, or cyclohexane, so that the organic phase is separated from the aqueous phase
[123That is, it is necessary to wash the organic phase with aqueous solution of sodium hydrogencarbonate
base is not too strong, dissolved in the ester hydrolysis
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The acid chloride is reacted with an ester to form another acid chloride and ester.
Purified, a lot of benzene ring should be solid, and the product is not high, and the reaction generated is removed by the reaction system.Then separated by distillation.
High boiling point, find a suitable solvent for crystallization or recrystallization.
The acid chloride is reacted with an ester to form another acid chloride and ester.
Purified, a lot of benzene ring should be solid, and the product is not high, and the reaction generated is removed by the reaction system.Then separated by distillation.
High boiling point, find a suitable solvent for crystallization or recrystallization.
More
VOTE