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How would you carry out complete reduction of enone to form saturated alcohol?
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Kevin Thorpe
How would you carry out complete reduction of enone to form saturated alcohol?
My own experience with Luche conditions is that they are fickle, and as likely to give you a mixture of 1,2 and 1,4 reduction products as not. For complete reduction of an enone I would go with Lithium triethyl borohydride to reduce the enone to ketone then sodium borohydride for ketone to alcohol. You can equally use catalytic hydrogenation for the enone reduction to ketone.
My own experience with Luche conditions is that they are fickle, and as likely to give you a mixture of 1,2 and 1,4 reduction products as not. For complete reduction of an enone I would go with Lithium triethyl borohydride to reduce the enone to ketone then sodium borohydride for ketone to alcohol. You can equally use catalytic hydrogenation for the enone reduction to ketone.
My own experience with Luche conditions is that they are fickle, and as likely to give you a mixture of 1,2 and 1,4 reduction products as not. For complete reduction of an enone I would go with Lithium triethyl borohydride to reduce the enone to ketone then sodium borohydride for ketone to alcohol. You can equally use catalytic hydrogenation for the enone reduction to ketone.
My own experience with Luche conditions is that they are fickle, and as likely to give you a mixture of 1,2 and 1,4 reduction products as not. For complete reduction of an enone I would go with Lithium triethyl borohydride to reduce the enone to ketone then sodium borohydride for ketone to alcohol. You can equally use catalytic hydrogenation for the enone reduction to ketone.
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