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+ Biochemistry
+ Chemistry
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Kaju Deka

Opening the imidazoline ring in tolazoline

Andrew Curl  Follow

The compound you have drawn is an imidazoline not an imidazole - big difference.

Imidazolines are fairly easily to hydroyse in both acidic and basic media, there is a good review here.

Imidazoles on the other hand are much more stable aromatic compounds and the hydrolytic ring opening is far from straighforward.

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