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Pyranose v/s Furanose form of Glucose and Fructose
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Lucka Jordán Penagos
Pyranose v/s Furanose form of Glucose and Fructose
You are correct that the same reasoning can be applied to fructose, and, as with glucose, the beta-pyranose form is most stable.
It is common in biochemistry textbooks, however, to draw fructose as a furanose. The reason for this is that fructose 6-phosphate is a common metabolite, and the phosphate group prevents the 6'-hydroxyl group from participating in ring closure. As a result, the free 5'-hydroxyl attacks the carbonyl, and a furanose is formed. Similarly, fructan biopolymers often contain 1,6 linkages that also prevent the pyranose formation.
You are correct that the same reasoning can be applied to fructose, and, as with glucose, the beta-pyranose form is most stable.
It is common in biochemistry textbooks, however, to draw fructose as a furanose. The reason for this is that fructose 6-phosphate is a common metabolite, and the phosphate group prevents the 6'-hydroxyl group from participating in ring closure. As a result, the free 5'-hydroxyl attacks the carbonyl, and a furanose is formed. Similarly, fructan biopolymers often contain 1,6 linkages that also prevent the pyranose formation.
You are correct that the same reasoning can be applied to fructose, and, as with glucose, the beta-pyranose form is most stable.
It is common in biochemistry textbooks, however, to draw fructose as a furanose. The reason for this is that fructose 6-phosphate is a common metabolite, and the phosphate group prevents the 6'-hydroxyl group from participating in ring closure. As a result, the free 5'-hydroxyl attacks the carbonyl, and a furanose is formed. Similarly, fructan biopolymers often contain 1,6 linkages that also prevent the pyranose formation.
You are correct that the same reasoning can be applied to fructose, and, as with glucose, the beta-pyranose form is most stable.
It is common in biochemistry textbooks, however, to draw fructose as a furanose. The reason for this is that fructose 6-phosphate is a common metabolite, and the phosphate group prevents the 6'-hydroxyl group from participating in ring closure. As a result, the free 5'-hydroxyl attacks the carbonyl, and a furanose is formed. Similarly, fructan biopolymers often contain 1,6 linkages that also prevent the pyranose formation.
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