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Rationalising the reactivity of phosphoryl chloride
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Al Chou
Rationalising the reactivity of phosphoryl chloride
AFAIK it's not a particularly common choice, but Vilsmeier reagents are sometimes used to convert alcohols to chlorides (see e.g. Tetrahedron Lett.1992,33 (34), 4901–4904). This explains the requirement for DMF/DMAc as solvent.
AFAIK it's not a particularly common choice, but Vilsmeier reagents are sometimes used to convert alcohols to chlorides (see e.g. Tetrahedron Lett.1992,33 (34), 4901–4904). This explains the requirement for DMF/DMAc as solvent.
AFAIK it's not a particularly common choice, but Vilsmeier reagents are sometimes used to convert alcohols to chlorides (see e.g. Tetrahedron Lett. 1992, 33 (34), 4901–4904). This explains the requirement for DMF/DMAc as solvent.
A reasonable mechanism is as follows:
(see also Org. Lett. 2002, 4 (4), 553–555 for a similar mechanism)
AFAIK it's not a particularly common choice, but Vilsmeier reagents are sometimes used to convert alcohols to chlorides (see e.g. Tetrahedron Lett. 1992, 33 (34), 4901–4904). This explains the requirement for DMF/DMAc as solvent.
A reasonable mechanism is as follows:
(see also Org. Lett. 2002, 4 (4), 553–555 for a similar mechanism)
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