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+ Organic

+ Chemistry

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Kashi S.

Reactivity of aldehydes vs ketones with ethylene glycol protecting groups?

Badi DukviL Follow

OK, thats different. Maybe you can brominate in the 2-position and treat the bromide with silveroxide in THF/H2O?

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Creator Follow

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I am not sure the method is really good but as a possible way to make it its acceptable. To make large amount I would hydrogenate 1,2-cyclohexanedione, I think that could work really well. The dione is in its enol-form.

That seems to be a method from Reaxys as well, and I agree that it is a good idea.

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Arslan Siddique Follow

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OK, thats different. Maybe you can brominate in the 2-position and treat the bromide with silveroxide in THF/H2O?

Haven't heard of that reaction, but I'm surprised it never occurred to me to brominate the alpha-carbon.

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Declan Hiam Follow

You can buy the dimer from Aldrich but its expensive. You can search on Scifinder or Reaxys to find a good method, its not worth the time to make one.

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Chukwuebuka Sunday Follow

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You can buy the dimer from Aldrich but its expensive. You can search on Scifinder or Reaxys to find a good method, its not worth the time to make one.

It's part of a theoretical exercise, so I don't need to synthesize it. But thanks.

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Atheism Now Follow

I think you get a mixture, its probably difficult to say how much of each. Better just try it.

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Cyril Gamage Follow

I am not sure the method is really good but as a possible way to make it its acceptable. To make large amount I would hydrogenate 1,2-cyclohexanedione, I think that could work really well. The dione is in its enol-form.

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Arooj Sajad Follow

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I think you get a mixture, its probably difficult to say how much of each. Better just try it.

Okay. I was considering using it for synthesizing 2-hydroxycyclohexanone from cyclohexanone. Although, now that you're here, is there an easier way to do it?

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