Home > Community > What are disadvantages of using sublimation vs. recrystallization as a method of purification?
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+ Purification
+ Recrystallization
+ Chemistry
+ Sublimation
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Albert Moody

What are disadvantages of using sublimation vs. recrystallization as a method of purification?

Chris Frost  Follow

Percent recovery if sublimate is not 100% complete since the fumes may be blown away especially if not executing proper sublimation process.

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David Petersen  Follow

I think a possible limitation might be that the compound to be purified should be volatile. And also, you don't really know when the sublimation is completely over. That's why we usually wait approximately 5 min after detecting the first crystals and turn over the heater... I mean, it's not a very accurate procedure.

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Blair  Follow

The most notable difference is that sublimation requires a volatile solid, whereas most solid can be recrystallized from a solvent system that is not too exotic.Recrystallizations tend to recover more pure product.In regards to green chemistry, sublimations are preferred as they generate no solvent waste.

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