Home >
Community >
What are the differences between activator and coactivator proteins?
Upvote
16
Downvote
+ Molecular biology
+ Biochemistry
+ Chemistry
Posted by
K. Joseph
What are the differences between activator and coactivator proteins?
Activators bind to transcription factors which have a weak activator function and increase the polymerase density (number of polymerases transcribing the gene). An example is VP16 binding to the Oct-1 transcription factor. In contrast, coactivators and corepressors bind to a transcription factor that in itself has no activator function and confer the property of activation or repressor to the DNA binding protein. An example is RBP/J is a DNA binding protein, but interaction with Mastermind (a coactivator) or Notch intracellular domain leads to activation of transcription.
Activators bind to transcription factors which have a weak activator function and increase the polymerase density (number of polymerases transcribing the gene). An example is VP16 binding to the Oct-1 transcription factor. In contrast, coactivators and corepressors bind to a transcription factor that in itself has no activator function and confer the property of activation or repressor to the DNA binding protein. An example is RBP/J is a DNA binding protein, but interaction with Mastermind (a coactivator) or Notch intracellular domain leads to activation of transcription.
Activators are proteins that bind to DNA and activate transcription. Coactivators are proteins that bind directly to activators and enhance their ability to activate transcription
OR
Activators are proteins that bind to DNA and activate transcription factors. Coactivators are proteins that bind directly to RNA polymerase II and increase its activity.
Activators are proteins that bind to DNA and activate transcription. Coactivators are proteins that bind directly to activators and enhance their ability to activate transcription
OR
Activators are proteins that bind to DNA and activate transcription factors. Coactivators are proteins that bind directly to RNA polymerase II and increase its activity.
Activators bind to transcription factors which have a weak activator function and increase the polymerase density (number of polymerases transcribing the gene). An example is VP16 binding to the Oct-1 transcription factor. In contrast, coactivators and corepressors bind to a transcription factor that in itself has no activator function and confer the property of activation or repressor to the DNA binding protein. An example is RBP/J is a DNA binding protein, but interaction with Mastermind (a coactivator) or Notch intracellular domain leads to activation of transcription.
Activators bind to transcription factors which have a weak activator function and increase the polymerase density (number of polymerases transcribing the gene). An example is VP16 binding to the Oct-1 transcription factor. In contrast, coactivators and corepressors bind to a transcription factor that in itself has no activator function and confer the property of activation or repressor to the DNA binding protein. An example is RBP/J is a DNA binding protein, but interaction with Mastermind (a coactivator) or Notch intracellular domain leads to activation of transcription.
More
VOTE
Activators are proteins that bind to DNA and activate transcription. Coactivators are proteins that bind directly to activators and enhance their ability to activate transcription
OR
Activators are proteins that bind to DNA and activate transcription factors. Coactivators are proteins that bind directly to RNA polymerase II and increase its activity.
Activators are proteins that bind to DNA and activate transcription. Coactivators are proteins that bind directly to activators and enhance their ability to activate transcription
OR
Activators are proteins that bind to DNA and activate transcription factors. Coactivators are proteins that bind directly to RNA polymerase II and increase its activity.
More
VOTE