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What difference between GC -MS ,GC- MS MS AND LC- MS ?
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Kevin Baker
What difference between GC -MS ,GC- MS MS AND LC- MS ?
GC (gas chromatography) is based on the volatility of the molecule at various temperatures while LC (liquid chromatography) is based on its solubility in various solvents (water, methanol, acetonitrile, isopropyl alcohol, hexane...). In both cases the chromatographic separation is based on its selective retention. MS, UV, RI, ELSD is just a tool to detect the molecule. It is the column that is the 'heart' of the separation.
GC (gas chromatography) is based on the volatility of the molecule at various temperatures while LC (liquid chromatography) is based on its solubility in various solvents (water, methanol, acetonitrile, isopropyl alcohol, hexane...). In both cases the chromatographic separation is based on its selective retention. MS, UV, RI, ELSD is just a tool to detect the molecule. It is the column that is the 'heart' of the separation.
LC is preffered in most laboratories because it is more universal then GC (it is estimated that only approx. 20-30 % of compounds can be analysed by GC). However, mobile phases in LC (organic solvents) are source of pollutants (waste) and are toxic for human health and the environment (their utlilization is required). In GC we have gases as mobile phase (in most cases hydrogen or hellium). Therefore, GC stends out in terms of green chemistry.
LC is preffered in most laboratories because it is more universal then GC (it is estimated that only approx. 20-30 % of compounds can be analysed by GC). However, mobile phases in LC (organic solvents) are source of pollutants (waste) and are toxic for human health and the environment (their utlilization is required). In GC we have gases as mobile phase (in most cases hydrogen or hellium). Therefore, GC stends out in terms of green chemistry.
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity
Both LC-MS and GC-MS are methods to detect the compounds in crude from fungi, plant, bacteria, and others. GC-MS = for volatile compounds LC-MS = for non volatile compounds
Both LC-MS and GC-MS are methods to detect the compounds in crude from fungi, plant, bacteria, and others. GC-MS = for volatile compounds LC-MS = for non volatile compounds
Gas Chromatography is a separation technique for volatile and thermally stable compounds. An inert gas is used as the mobile phase. Liquid Chromatography is a separation technique for high molecular weight and non-volatile samples. A combination of liquids is used as the mobile phase. Hence the requirement for a sample to be analyzed by GC is it's volatility and thermal stability while in LC it is the solubility in the mobile phase. MS is a detector that is added to either GC or LC. MS provides a mass spectrum which will be useful for characterizing the compound. In GCMS, the compound is fragmented only once. In GC/MS/MS, a fragment from the compound is further fragmented by colliding it with a gas like Argon to produce daughter ions. This will produce an MS/MS spectrum which will enable the user to precisely quantify the target by eliminating any possible matrix interference. There are different scan modes available in GC/MS/MS.
Gas Chromatography is a separation technique for volatile and thermally stable compounds. An inert gas is used as the mobile phase. Liquid Chromatography is a separation technique for high molecular weight and non-volatile samples. A combination of liquids is used as the mobile phase. Hence the requirement for a sample to be analyzed by GC is it's volatility and thermal stability while in LC it is the solubility in the mobile phase. MS is a detector that is added to either GC or LC. MS provides a mass spectrum which will be useful for characterizing the compound. In GCMS, the compound is fragmented only once. In GC/MS/MS, a fragment from the compound is further fragmented by colliding it with a gas like Argon to produce daughter ions. This will produce an MS/MS spectrum which will enable the user to precisely quantify the target by eliminating any possible matrix interference. There are different scan modes available in GC/MS/MS.
Dear Dhia, While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds. Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity. Sincerely yours, Homayoon.
Dear Dhia, While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds. Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity. Sincerely yours, Homayoon.
Dear Dhia, While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds. Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity. Sincerely yours, Homayoon.
Dear Dhia, While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds. Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity. Sincerely yours, Homayoon.
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
First, the MS/MS difference in MS is that MS is just about the use after the column, but MS/MS in addition to a MS after the column also a MS before the column (without columns) also done.
Secondly, 1.Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. 2.Both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity. 3.GC-MS is the preferred standard for forensic identification, and it is also the preferred machine in terms of costs and operation. To find out the difference between LC MS and GC MS, it's better to use the link below: http://www.differencebetween.net/science/difference-between-gc-ms-and-lc-ms/
First, the MS/MS difference in MS is that MS is just about the use after the column, but MS/MS in addition to a MS after the column also a MS before the column (without columns) also done.
Secondly, 1.Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. 2.Both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity. 3.GC-MS is the preferred standard for forensic identification, and it is also the preferred machine in terms of costs and operation. To find out the difference between LC MS and GC MS, it's better to use the link below: http://www.differencebetween.net/science/difference-between-gc-ms-and-lc-ms/
In LC-MS, solvent i.e: Water, Acetonitrile, Methanol, Ethanol, Propanol, Isopropanol are used as mobile phase where in GC-MS, gas i.e: He, H have been used as mobile phase.
In LC-MS, solvent i.e: Water, Acetonitrile, Methanol, Ethanol, Propanol, Isopropanol are used as mobile phase where in GC-MS, gas i.e: He, H have been used as mobile phase.
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
Very good answers. I would like to add that for each of these techniques you need a specific, dedicated instrument and they are quite expensive instruments... GC-MS/MS and LC-MS/MS are much more expensive than (single quadrupole) GC-MS and LC-MS. You need to know well your application!
Very good answers. I would like to add that for each of these techniques you need a specific, dedicated instrument and they are quite expensive instruments... GC-MS/MS and LC-MS/MS are much more expensive than (single quadrupole) GC-MS and LC-MS. You need to know well your application!
While GC-MS and LC-MS differ fundamentally by mobile phase, GC-MS has the advantage of NIST library which can predict the compounds qualitatively based on the mass spectra matching. Without standard, predicting/quantifying the compounds is not possible in LC-MS and both the instruments cannot be used for quantification. GC-MS/MS is a quantitative equipment which needs standard for calibration and quantification. The limit of detection in GC-MS/MS is ppt level and it is ppm in case of GC-MS and ppb on LC-MS. So, LC-MS and GC-MS/MS needs standard for doing any kind of analysis.
While GC-MS and LC-MS differ fundamentally by mobile phase, GC-MS has the advantage of NIST library which can predict the compounds qualitatively based on the mass spectra matching. Without standard, predicting/quantifying the compounds is not possible in LC-MS and both the instruments cannot be used for quantification. GC-MS/MS is a quantitative equipment which needs standard for calibration and quantification. The limit of detection in GC-MS/MS is ppt level and it is ppm in case of GC-MS and ppb on LC-MS. So, LC-MS and GC-MS/MS needs standard for doing any kind of analysis.
GC (gas chromatography) is based on the volatility of the molecule at various temperatures while LC (liquid chromatography) is based on its solubility in various solvents (water, methanol, acetonitrile, isopropyl alcohol, hexane...).
In both cases the chromatographic separation is based on its selective retention. MS, UV, RI, ELSD is just a tool to detect the molecule. It is the column that is the 'heart' of the separation.
GC (gas chromatography) is based on the volatility of the molecule at various temperatures while LC (liquid chromatography) is based on its solubility in various solvents (water, methanol, acetonitrile, isopropyl alcohol, hexane...).
In both cases the chromatographic separation is based on its selective retention. MS, UV, RI, ELSD is just a tool to detect the molecule. It is the column that is the 'heart' of the separation.
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VOTE
LC is preffered in most laboratories because it is more universal then GC (it is estimated that only approx. 20-30 % of compounds can be analysed by GC). However, mobile phases in LC (organic solvents) are source of pollutants (waste) and are toxic for human health and the environment (their utlilization is required). In GC we have gases as mobile phase (in most cases hydrogen or hellium). Therefore, GC stends out in terms of green chemistry.
LC is preffered in most laboratories because it is more universal then GC (it is estimated that only approx. 20-30 % of compounds can be analysed by GC). However, mobile phases in LC (organic solvents) are source of pollutants (waste) and are toxic for human health and the environment (their utlilization is required). In GC we have gases as mobile phase (in most cases hydrogen or hellium). Therefore, GC stends out in terms of green chemistry.
More
VOTE
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity
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VOTE
Both LC-MS and GC-MS are methods to detect the compounds in crude from fungi, plant, bacteria, and others.
GC-MS = for volatile compounds
LC-MS = for non volatile compounds
Both LC-MS and GC-MS are methods to detect the compounds in crude from fungi, plant, bacteria, and others.
GC-MS = for volatile compounds
LC-MS = for non volatile compounds
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VOTE
Gas Chromatography is a separation technique for volatile and thermally stable compounds. An inert gas is used as the mobile phase. Liquid Chromatography is a separation technique for high molecular weight and non-volatile samples. A combination of liquids is used as the mobile phase. Hence the requirement for a sample to be analyzed by GC is it's volatility and thermal stability while in LC it is the solubility in the mobile phase. MS is a detector that is added to either GC or LC. MS provides a mass spectrum which will be useful for characterizing the compound. In GCMS, the compound is fragmented only once. In GC/MS/MS, a fragment from the compound is further fragmented by colliding it with a gas like Argon to produce daughter ions. This will produce an MS/MS spectrum which will enable the user to precisely quantify the target by eliminating any possible matrix interference. There are different scan modes available in GC/MS/MS.
Gas Chromatography is a separation technique for volatile and thermally stable compounds. An inert gas is used as the mobile phase. Liquid Chromatography is a separation technique for high molecular weight and non-volatile samples. A combination of liquids is used as the mobile phase. Hence the requirement for a sample to be analyzed by GC is it's volatility and thermal stability while in LC it is the solubility in the mobile phase. MS is a detector that is added to either GC or LC. MS provides a mass spectrum which will be useful for characterizing the compound. In GCMS, the compound is fragmented only once. In GC/MS/MS, a fragment from the compound is further fragmented by colliding it with a gas like Argon to produce daughter ions. This will produce an MS/MS spectrum which will enable the user to precisely quantify the target by eliminating any possible matrix interference. There are different scan modes available in GC/MS/MS.
More
VOTE
Dear Dhia,
While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds.
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity.
Sincerely yours, Homayoon.
Dear Dhia,
While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds.
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity.
Sincerely yours, Homayoon.
More
VOTE
Dear Dhia,
While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds.
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity.
Sincerely yours, Homayoon.
Dear Dhia,
While gas chromatography–mass spectrometry (GC–MS) has beenwidely recognized as the " gold standard " in forensic testing, use of liquid chromatography–tandem mass spectrometry (LC–MS-MS) is be-coming more common. This is because LC–MS-MS offers several ad-vantages over GC–MS such as quicker and less extensive extraction procedures and the ability to identify and measure a broader range of compounds.
Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer. Additionally, both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity.
Sincerely yours, Homayoon.
More
VOTE
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
More
VOTE
First, the MS/MS difference in MS is that MS is just about the use after the column, but MS/MS in addition to a MS after the column also a MS before the column (without columns) also done.
Secondly,
1.Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer.
2.Both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity.
3.GC-MS is the preferred standard for forensic identification, and it is also the preferred machine in terms of costs and operation.
To find out the difference between LC MS and GC MS, it's better to use the link below:
http://www.differencebetween.net/science/difference-between-gc-ms-and-lc-ms/
First, the MS/MS difference in MS is that MS is just about the use after the column, but MS/MS in addition to a MS after the column also a MS before the column (without columns) also done.
Secondly,
1.Both LC-MS and GC-MS are methods to separate chemicals in a mixture or a sample. Both methods separate the chemicals by chromatography first, then further examine and identify them by the mass spectrometer.
2.Both methods require a mobile phase and a stationary phase. The only difference is that LC-MS uses a solvent as its mobile phase, while GC-MS uses inert gases (like helium) in the same capacity.
3.GC-MS is the preferred standard for forensic identification, and it is also the preferred machine in terms of costs and operation.
To find out the difference between LC MS and GC MS, it's better to use the link below:
http://www.differencebetween.net/science/difference-between-gc-ms-and-lc-ms/
More
VOTE
In LC-MS, solvent i.e: Water, Acetonitrile, Methanol, Ethanol, Propanol, Isopropanol are used as mobile phase where in GC-MS, gas i.e: He, H have been used as mobile phase.
In LC-MS, solvent i.e: Water, Acetonitrile, Methanol, Ethanol, Propanol, Isopropanol are used as mobile phase where in GC-MS, gas i.e: He, H have been used as mobile phase.
More
VOTE
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
GC is used for analyzing volatile organics, and generally separating by boiling points. GCMS indicates that a mass spectrometer is used as the detector for the GC. GCMSMS, indicates that the instrument is capable of isolating and fragmenting a desired molecular weight, and the resulting fragments can then be analyzed by mass spectrometry. LC is a separation performed in the liquid phase and is generally used for larger more polar molecules which are incompatible with GC. When a mass spectrometer is used as a detector, you have LCMS. There really are significant differences, but in terms of which one is best, it simply depends on the application. They each have their uses.
More
VOTE
Very good answers. I would like to add that for each of these techniques you need a specific, dedicated instrument and they are quite expensive instruments...
GC-MS/MS and LC-MS/MS are much more expensive than (single quadrupole) GC-MS and LC-MS. You need to know well your application!
Very good answers. I would like to add that for each of these techniques you need a specific, dedicated instrument and they are quite expensive instruments...
GC-MS/MS and LC-MS/MS are much more expensive than (single quadrupole) GC-MS and LC-MS. You need to know well your application!
More
VOTE
While GC-MS and LC-MS differ fundamentally by mobile phase, GC-MS has the advantage of NIST library which can predict the compounds qualitatively based on the mass spectra matching. Without standard, predicting/quantifying the compounds is not possible in LC-MS and both the instruments cannot be used for quantification.
GC-MS/MS is a quantitative equipment which needs standard for calibration and quantification. The limit of detection in GC-MS/MS is ppt level and it is ppm in case of GC-MS and ppb on LC-MS.
So, LC-MS and GC-MS/MS needs standard for doing any kind of analysis.
While GC-MS and LC-MS differ fundamentally by mobile phase, GC-MS has the advantage of NIST library which can predict the compounds qualitatively based on the mass spectra matching. Without standard, predicting/quantifying the compounds is not possible in LC-MS and both the instruments cannot be used for quantification.
GC-MS/MS is a quantitative equipment which needs standard for calibration and quantification. The limit of detection in GC-MS/MS is ppt level and it is ppm in case of GC-MS and ppb on LC-MS.
So, LC-MS and GC-MS/MS needs standard for doing any kind of analysis.
More
VOTE