EC50 value: The concentration of the maximum clinical effect (which can be inhibited or stimulated) at 50%of the drug. This is a medicinal term. ED50 value: 50%of individuals show the effective dose (rather than concentration) of the drug during specific drugs. IC50 value: The concentration of inhibitors when reaching 50%inhibitory effect. PIC50 value: the negative number of 10 of the IC50 value. Ki value: The concentration of inhibitors is detected when the 50%inhibitory effect is detected (obtained by Michaelis-Menten dynamic calculation). KD value: The equilibrium constant of the complex composed of two or more biomolecules is separated into components; 4. LOGP, LOGD, Alogp, Alogd, Clogp, Clogd logp: Partition Coefficient p \u003d Concentration of Drug in Octanol/Concentration of Drug in Aquate Copychet ( The ratio of the concentration of sink and water) logd: distribution coefficient (distribution) d \u003d (under specific pH) compounds to all the combinations of ionization and non -solution forms in the total concentration of orthopedic and water [ 123] For example, AH \u003d A-+H+ p \u003d Octanol/Water d \u003d (+) Octanol/(+) Water ACD (ACD/PHYSCHEM Suite) is a software that predicts the materialized nature of compounds Among them, ACD/LOGD module can quickly and accurately predict the oil and water distribution coefficient containing one or more electrocable ionized compounds, which correctly reflect the true line of the two phases of oil and water under the given pH value. The value of the logd measured by ACD is referred to as Alogd for short; the value of the logp measured by ACD is referred to as Alogp. As the name suggests, Calculated (calculated value) LOGP for short referred to as ClogP; Calculated (calculated value) LOGD referred to as Clogd.
EC50 value: The concentration of the maximum clinical effect (which can be inhibited or stimulated) at 50%of the drug. This is a medicinal term. ED50 value: 50%of individuals show the effective dose (rather than concentration) of the drug during specific drugs. IC50 value: The concentration of inhibitors when reaching 50%inhibitory effect. PIC50 value: the negative number of 10 of the IC50 value. Ki value: The concentration of inhibitors is detected when the 50%inhibitory effect is detected (obtained by Michaelis-Menten dynamic calculation). KD value: The equilibrium constant of the complex composed of two or more biomolecules is separated into components; 4. LOGP, LOGD, Alogp, Alogd, Clogp, Clogd logp: Partition Coefficient p \u003d Concentration of Drug in Octanol/Concentration of Drug in Aquate Copychet ( The ratio of the concentration of sink and water) logd: distribution coefficient (distribution) d \u003d (under specific pH) compounds to all the combinations of ionization and non -solution forms in the total concentration of orthopedic and water [ 123] For example, AH \u003d A-+H+ p \u003d Octanol/Water d \u003d (+) Octanol/(+) Water ACD (ACD/PHYSCHEM Suite) is a software that predicts the materialized nature of compounds Among them, ACD/LOGD module can quickly and accurately predict the oil and water distribution coefficient containing one or more electrocable ionized compounds, which correctly reflect the true line of the two phases of oil and water under the given pH value. The value of the logd measured by ACD is referred to as Alogd for short; the value of the logp measured by ACD is referred to as Alogp. As the name suggests, Calculated (calculated value) LOGP for short referred to as ClogP; Calculated (calculated value) LOGD referred to as Clogd.
ED50 value: 50%of individuals show the effective dose (rather than concentration) of the drug during specific drugs.
IC50 value: The concentration of inhibitors when reaching 50%inhibitory effect.
PIC50 value: the negative number of 10 of the IC50 value.
Ki value: The concentration of inhibitors is detected when the 50%inhibitory effect is detected (obtained by Michaelis-Menten dynamic calculation).
KD value: The equilibrium constant of the complex composed of two or more biomolecules is separated into components;
4. LOGP, LOGD, Alogp, Alogd, Clogp, Clogd
logp: Partition Coefficient
p \u003d Concentration of Drug in Octanol/Concentration of Drug in Aquate Copychet ( The ratio of the concentration of sink and water)
logd: distribution coefficient (distribution)
d \u003d (under specific pH) compounds to all the combinations of ionization and non -solution forms in the total concentration of orthopedic and water [ 123] For example, AH \u003d A-+H+
p \u003d Octanol/Water
d \u003d (+) Octanol/(+) Water
ACD (ACD/PHYSCHEM Suite) is a software that predicts the materialized nature of compounds Among them,
ACD/LOGD module can quickly and accurately predict the oil and water distribution coefficient containing one or more electrocable ionized compounds, which correctly reflect the true line of the two phases of oil and water under the given pH value. The value of the logd measured by ACD is referred to as Alogd for short; the value of the logp measured by ACD is referred to as Alogp.
As the name suggests, Calculated (calculated value) LOGP for short referred to as ClogP; Calculated (calculated value) LOGD referred to as Clogd.
ED50 value: 50%of individuals show the effective dose (rather than concentration) of the drug during specific drugs.
IC50 value: The concentration of inhibitors when reaching 50%inhibitory effect.
PIC50 value: the negative number of 10 of the IC50 value.
Ki value: The concentration of inhibitors is detected when the 50%inhibitory effect is detected (obtained by Michaelis-Menten dynamic calculation).
KD value: The equilibrium constant of the complex composed of two or more biomolecules is separated into components;
4. LOGP, LOGD, Alogp, Alogd, Clogp, Clogd
logp: Partition Coefficient
p \u003d Concentration of Drug in Octanol/Concentration of Drug in Aquate Copychet ( The ratio of the concentration of sink and water)
logd: distribution coefficient (distribution)
d \u003d (under specific pH) compounds to all the combinations of ionization and non -solution forms in the total concentration of orthopedic and water [ 123] For example, AH \u003d A-+H+
p \u003d Octanol/Water
d \u003d (+) Octanol/(+) Water
ACD (ACD/PHYSCHEM Suite) is a software that predicts the materialized nature of compounds Among them,
ACD/LOGD module can quickly and accurately predict the oil and water distribution coefficient containing one or more electrocable ionized compounds, which correctly reflect the true line of the two phases of oil and water under the given pH value. The value of the logd measured by ACD is referred to as Alogd for short; the value of the logp measured by ACD is referred to as Alogp.
As the name suggests, Calculated (calculated value) LOGP for short referred to as ClogP; Calculated (calculated value) LOGD referred to as Clogd.
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