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What is the difference between acid and base catalyzed opening of epoxides?
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+ Chemical reactions
+ Biochemistry
+ Acids
+ Peroxides
+ Chemistry
+ Organic chemistry
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Kostas Ampatzis
What is the difference between acid and base catalyzed opening of epoxides?
OH- opening is an SN2 reaction and gives a trans diol. Acid catalyzed hydrolysis proceeds thru a carbocation intermediate and gives mixed stereochemistry.
OH- opening is an SN2 reaction and gives a trans diol. Acid catalyzed hydrolysis proceeds thru a carbocation intermediate and gives mixed stereochemistry.
OH- opening is an SN2 reaction and gives a trans diol. Acid catalyzed hydrolysis proceeds thru a carbocation intermediate and gives mixed stereochemistry.
OH- opening is an SN2 reaction and gives a trans diol. Acid catalyzed hydrolysis proceeds thru a carbocation intermediate and gives mixed stereochemistry.
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It will open on the more highly substituted end, which provides the more stable carbocation.
It will open on the more highly substituted end, which provides the more stable carbocation.
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