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What is the different between lipoprotein and proteolipid?
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+ Biochemistry
+ Lipoproteins
+ Chemistry
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Neil Fullagar
What is the different between lipoprotein and proteolipid?
In 1951, proteins that were soluble in organic solvents such as chloroform-methanol were found in rat brain myelin by Folch and Lees (better known for devising the most common method for lipid extraction), who coined the term ‘proteolipid’. However it was another twenty years before it was shown that these contained covalently bound fatty acids and so differed from the plasma lipoproteins. Such lipid-modified proteins are now known to be widespread in nature with a variety of important functions in animals, plants and bacteria. Proteolipids can be defined as all proteins containing covalently bound lipid moieties, including fatty acids, isoprenoids, cholesterol and glycosylphosphatidylinositol. The last of these (‘GPI-anchored proteins’). The term ‘lipoprotein’ is also used to describe such compounds on occasion, but to avoid confusion this might be better reserved for the non-covalently linked lipid-protein complexes of the type found in plasma.
In 1951, proteins that were soluble in organic solvents such as chloroform-methanol were found in rat brain myelin by Folch and Lees (better known for devising the most common method for lipid extraction), who coined the term ‘proteolipid’. However it was another twenty years before it was shown that these contained covalently bound fatty acids and so differed from the plasma lipoproteins. Such lipid-modified proteins are now known to be widespread in nature with a variety of important functions in animals, plants and bacteria. Proteolipids can be defined as all proteins containing covalently bound lipid moieties, including fatty acids, isoprenoids, cholesterol and glycosylphosphatidylinositol. The last of these (‘GPI-anchored proteins’). The term ‘lipoprotein’ is also used to describe such compounds on occasion, but to avoid confusion this might be better reserved for the non-covalently linked lipid-protein complexes of the type found in plasma.
In 1951, proteins that were soluble in organic solvents such as chloroform-methanol were found in rat brain myelin by Folch and Lees (better known for devising the most common method for lipid extraction), who coined the term ‘proteolipid’. However it was another twenty years before it was shown that these contained covalently bound fatty acids and so differed from the plasma lipoproteins. Such lipid-modified proteins are now known to be widespread in nature with a variety of important functions in animals, plants and bacteria. Proteolipids can be defined as all proteins containing covalently bound lipid moieties, including fatty acids, isoprenoids, cholesterol and glycosylphosphatidylinositol. The last of these (‘GPI-anchored proteins’). The term ‘lipoprotein’ is also used to describe such compounds on occasion, but to avoid confusion this might be better reserved for the non-covalently linked lipid-protein complexes of the type found in plasma.
In 1951, proteins that were soluble in organic solvents such as chloroform-methanol were found in rat brain myelin by Folch and Lees (better known for devising the most common method for lipid extraction), who coined the term ‘proteolipid’. However it was another twenty years before it was shown that these contained covalently bound fatty acids and so differed from the plasma lipoproteins. Such lipid-modified proteins are now known to be widespread in nature with a variety of important functions in animals, plants and bacteria. Proteolipids can be defined as all proteins containing covalently bound lipid moieties, including fatty acids, isoprenoids, cholesterol and glycosylphosphatidylinositol. The last of these (‘GPI-anchored proteins’). The term ‘lipoprotein’ is also used to describe such compounds on occasion, but to avoid confusion this might be better reserved for the non-covalently linked lipid-protein complexes of the type found in plasma.
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