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Lance Chambers

What is the germ layer origin of human lung fibroblasts?

Allen Inks  Follow

All normal fibroblasts are mesenchymal in origin, including lung fibroblasts. In certain situations, usually injury related, epithelial cells can undergo an epithelial to mesenchymal transition (EMT).

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Haider Ali  Follow
Even dermal fibroblasts?More
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Jeff Iverson  Follow
Yes, all fibroblasts with the exception I listed in my answer.More
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Andrew Wrigley  Follow

The table at http://genome-mirror.duhs.duke.edu/ENCODE/cellTypes.html lists many commercially available cell lines. The four lung fibroblast lines, including adult and fetal, are listed as endodermal in origin.

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