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Lou Heavner

What is the role of glacial acetic acid during the acetylation of aniline?

David Cislo  Follow

100% pure acetic acid, when freeze it appears as ice. There know as glacial acetic acid.

Function

  1. Glacial acetic acid is an excellent polar solvent. It is frequently used as a solvent for recrystallization to purify organic compounds.
  2. Glacial acetic acid is used in analytical chemistry for the estimation of weakly alkaline substance.

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Dave LaFrenere  Follow

Glacial acetic acid is used because it is an excellent polar protic solvent capable of dissolving acetanilide. For the process, acetanilide is first dissolved in the solvent, glacial acetic acid, by warming. It's just a solvent to dissolve anisole (both are polar). Acetanilide is an important organic compound that is vastly used in the pharmaceutical industry. It is an odourless, white, solid, or flaky compound. Its preparation method is used to introduce students to the synthesis of organic compounds in chemistry labs. It is prepared by acetylation of aniline.

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