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Larry King
What is the significance of BET analysis of nanoparticles for drug...
The solution to the problem of drug delivery by nanoparticles is the toxicity of the tandem, rapid delivery to the target and release of the drug. The BET theory is an approximate theory of adsorption in porous bodies in closed systems. The human body is an open system with a high concentration of organic molecules up to 30 percent and therefore it is not correct to use the BET theory for this problem. I advise you to see the article
The solution to the problem of drug delivery by nanoparticles is the toxicity of the tandem, rapid delivery to the target and release of the drug. The BET theory is an approximate theory of adsorption in porous bodies in closed systems. The human body is an open system with a high concentration of organic molecules up to 30 percent and therefore it is not correct to use the BET theory for this problem. I advise you to see the article
Saeid Moghassemi . The solubility of nanoparticles is determined by the Kelvin (Thomson) equation in an aqueous solution in a closed system. Her predictive ability for the human body will be doubtful.
Saeid Moghassemi . The solubility of nanoparticles is determined by the Kelvin (Thomson) equation in an aqueous solution in a closed system. Her predictive ability for the human body will be doubtful.
Rabia Raja You should start a new question to avoid confusing this thread. In that way you'll get the benefit of all experts. BET is a test for dry powders and thus one would not conduct a BET measurement on a gold sol. You will destroy the 'nano-ness' of colloidal gold as there are no free, independent, discrete particles < 100 nm in a powder. See, for example (registration required): Know the Basics of Dispersing Nanosize Materials https://www.malvernpanalytical.com/en/learn/events-and-training/webinars/W190528DispNanoMat.html My suggestion is to work with the surface area moment mean (Sauter Mean Diameter, D[3.2]) obtained from a suitable technique (e.g. a conversion in light scattering from volume or intensity; the optical properties for gold necessary for this conversion are well known). Then the SSA is 6/(D[3,2]*Density) and you get a single estimated SSA for your material.
Rabia Raja You should start a new question to avoid confusing this thread. In that way you'll get the benefit of all experts. BET is a test for dry powders and thus one would not conduct a BET measurement on a gold sol. You will destroy the 'nano-ness' of colloidal gold as there are no free, independent, discrete particles < 100 nm in a powder. See, for example (registration required): Know the Basics of Dispersing Nanosize Materials https://www.malvernpanalytical.com/en/learn/events-and-training/webinars/W190528DispNanoMat.html My suggestion is to work with the surface area moment mean (Sauter Mean Diameter, D[3.2]) obtained from a suitable technique (e.g. a conversion in light scattering from volume or intensity; the optical properties for gold necessary for this conversion are well known). Then the SSA is 6/(D[3,2]*Density) and you get a single estimated SSA for your material.
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7 (January 2017)
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7 (January 2017)
BET analysis of nano-particles has strong significance for drug delivery. Basically, Multipoint BET (Brunauer-Emmett-Teller) analysis is applied for the total surface area calculation. Couples of them are: 1. This is highly useful for surface area calculation. BET Surface Area Analysis provides specific nanoparticle surface area evaluation via nitrogen multilayer adsorption, measured as a function of relative pressure. This can distinguish high surface area and low surface area 2. Evaluation of pore surface area. The nature of the porous structures can be examined by BET analysis. 3. Characterization of mesoporous surfaces area. The characteristics of calcined mesoporous silica materials can be analysed by BET for examining their specific surface areas.
Importantly, the morphological properties such as high surface area, large pore volume and the narrow particle size distribution are well suited for the application of nano-encapsulation in drug delivery systems.
BET analysis of nano-particles has strong significance for drug delivery. Basically, Multipoint BET (Brunauer-Emmett-Teller) analysis is applied for the total surface area calculation. Couples of them are: 1. This is highly useful for surface area calculation. BET Surface Area Analysis provides specific nanoparticle surface area evaluation via nitrogen multilayer adsorption, measured as a function of relative pressure. This can distinguish high surface area and low surface area 2. Evaluation of pore surface area. The nature of the porous structures can be examined by BET analysis. 3. Characterization of mesoporous surfaces area. The characteristics of calcined mesoporous silica materials can be analysed by BET for examining their specific surface areas.
Importantly, the morphological properties such as high surface area, large pore volume and the narrow particle size distribution are well suited for the application of nano-encapsulation in drug delivery systems.
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7 (January 2017)
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7 (January 2017)
By BET (Brunauer, Emmett and Teller) the specific surface area of a sample is measured – including the pore size distribution. This information is used to predict the dissolution rate, as this rate is proportional to the specific surface area. Thus, the surface area can be used to predict bioavailability. Further it is useful in evaluation of product performance and manufacturing consistency.
By BET (Brunauer, Emmett and Teller) the specific surface area of a sample is measured – including the pore size distribution. This information is used to predict the dissolution rate, as this rate is proportional to the specific surface area. Thus, the surface area can be used to predict bioavailability. Further it is useful in evaluation of product performance and manufacturing consistency.
The solution to the problem of drug delivery by nanoparticles is the toxicity of the tandem, rapid delivery to the target and release of the drug. The BET theory is an approximate theory of adsorption in porous bodies in closed systems. The human body is an open system with a high concentration of organic molecules up to 30 percent and therefore it is not correct to use the BET theory for this problem. I advise you to see the article
Article Drug delivery and nanoparticles: Applications and hazards
The solution to the problem of drug delivery by nanoparticles is the toxicity of the tandem, rapid delivery to the target and release of the drug. The BET theory is an approximate theory of adsorption in porous bodies in closed systems. The human body is an open system with a high concentration of organic molecules up to 30 percent and therefore it is not correct to use the BET theory for this problem. I advise you to see the article
Article Drug delivery and nanoparticles: Applications and hazards
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Dear all,
any one of you has an idea of sample preparation for the BET test of gold nanoparticles.
Dear all,
any one of you has an idea of sample preparation for the BET test of gold nanoparticles.
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Saeid Moghassemi .
The solubility of nanoparticles is determined by the Kelvin (Thomson) equation in an aqueous solution in a closed system. Her predictive ability for the human body will be doubtful.
Saeid Moghassemi .
The solubility of nanoparticles is determined by the Kelvin (Thomson) equation in an aqueous solution in a closed system. Her predictive ability for the human body will be doubtful.
More
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Rabia Raja
You should start a new question to avoid confusing this thread. In that way you'll get the benefit of all experts.
BET is a test for dry powders and thus one would not conduct a BET measurement on a gold sol. You will destroy the 'nano-ness' of colloidal gold as there are no free, independent, discrete particles < 100 nm in a powder. See, for example (registration required):
Know the Basics of Dispersing Nanosize Materials
https://www.malvernpanalytical.com/en/learn/events-and-training/webinars/W190528DispNanoMat.html
My suggestion is to work with the surface area moment mean (Sauter Mean Diameter, D[3.2]) obtained from a suitable technique (e.g. a conversion in light scattering from volume or intensity; the optical properties for gold necessary for this conversion are well known). Then the SSA is 6/(D[3,2]*Density) and you get a single estimated SSA for your material.
Rabia Raja
You should start a new question to avoid confusing this thread. In that way you'll get the benefit of all experts.
BET is a test for dry powders and thus one would not conduct a BET measurement on a gold sol. You will destroy the 'nano-ness' of colloidal gold as there are no free, independent, discrete particles < 100 nm in a powder. See, for example (registration required):
Know the Basics of Dispersing Nanosize Materials
https://www.malvernpanalytical.com/en/learn/events-and-training/webinars/W190528DispNanoMat.html
My suggestion is to work with the surface area moment mean (Sauter Mean Diameter, D[3.2]) obtained from a suitable technique (e.g. a conversion in light scattering from volume or intensity; the optical properties for gold necessary for this conversion are well known). Then the SSA is 6/(D[3,2]*Density) and you get a single estimated SSA for your material.
More
VOTE
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7
(January 2017)
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7
(January 2017)
More
VOTE
Dear Anish,
BET analysis of nano-particles has strong significance for drug delivery. Basically, Multipoint BET (Brunauer-Emmett-Teller) analysis is applied for the total surface area calculation. Couples of them are:
1. This is highly useful for surface area calculation. BET Surface Area Analysis provides specific nanoparticle surface area evaluation via nitrogen multilayer adsorption, measured as a function of relative pressure. This can distinguish high surface area and low surface area
2. Evaluation of pore surface area. The nature of the porous structures can be examined by BET analysis.
3. Characterization of mesoporous surfaces area. The characteristics of calcined mesoporous silica materials can be analysed by BET for examining their specific surface areas.
Importantly, the morphological properties such as high surface area, large pore volume and the narrow particle size distribution are well suited for the application of nano-encapsulation in drug delivery systems.
Ashish
Dear Anish,
BET analysis of nano-particles has strong significance for drug delivery. Basically, Multipoint BET (Brunauer-Emmett-Teller) analysis is applied for the total surface area calculation. Couples of them are:
1. This is highly useful for surface area calculation. BET Surface Area Analysis provides specific nanoparticle surface area evaluation via nitrogen multilayer adsorption, measured as a function of relative pressure. This can distinguish high surface area and low surface area
2. Evaluation of pore surface area. The nature of the porous structures can be examined by BET analysis.
3. Characterization of mesoporous surfaces area. The characteristics of calcined mesoporous silica materials can be analysed by BET for examining their specific surface areas.
Importantly, the morphological properties such as high surface area, large pore volume and the narrow particle size distribution are well suited for the application of nano-encapsulation in drug delivery systems.
Ashish
More
VOTE
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7
(January 2017)
Generally specific surface area measurements give an indication of the available surface area which should correlate both with solubility and dissolution rate and therefore with bioavailability. It is necessary therefore to try to make poorly soluble active ingredients in nano form in order to enhance dissolution. Read the chapter: 'Characterization of Nanomaterials' In book: 'Metrology and Standardization of Nanotechnology' DOI: 10.1002/9783527800308.ch7
(January 2017)
More
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is it possible to having Low BET (20m2/g) with high drug loading more than 80%?
and how?
is it possible to having Low BET (20m2/g) with high drug loading more than 80%?
and how?
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By BET (Brunauer, Emmett and Teller) the specific surface area of a sample is measured – including the pore size distribution. This information is used to predict the dissolution rate, as this rate is proportional to the specific surface area. Thus, the surface area can be used to predict bioavailability. Further it is useful in evaluation of product performance and manufacturing consistency.
By BET (Brunauer, Emmett and Teller) the specific surface area of a sample is measured – including the pore size distribution. This information is used to predict the dissolution rate, as this rate is proportional to the specific surface area. Thus, the surface area can be used to predict bioavailability. Further it is useful in evaluation of product performance and manufacturing consistency.
More
VOTE