Home > Community > Why is glacial acetic acid used during the preparation of acetanilide from aniline?
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Larry Hanson

Why is glacial acetic acid used during the preparation of acetanilide from aniline?

Blake Davis  Follow

Glacial acetic acid is used because it is an excellent polar protic solvent capable of dissolving acetanilide. For the process, acetanilide is first dissolved in the solvent, glacial acetic acid, by warming. It's just a solvent to dissolve anisole (both are polar). Answer: Acetylation of phenols with glacial acetic acid in presence of phospho- rus pentoxide gives the O-acetyl derivatives in yields of 10 to 40 per cent.

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Bryan Michaels-Lex  Follow

Theory: Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. ... Zinc is used to prevent the oxidation of aniline during the chemical reaction. Acetanilide is medicinally important and it is used as febrifuge.

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