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Why is the Friedel-Crafts alkylation of nitrobenzene disfavoured?
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Mahesh Somasundaram
Why is the Friedel-Crafts alkylation of nitrobenzene disfavoured?
The nitro group is so deactivating that yields are really poor for Friedel-Crafts reactions with nitrobenzene; not even the meta-substituted product is found in good yield. In fact, nitrobenzene is actually used as a solvent in Friedel-Crafts reactions.
The nitro group is so deactivating that yields are really poor for Friedel-Crafts reactions with nitrobenzene; not even the meta-substituted product is found in good yield. In fact, nitrobenzene is actually used as a solvent in Friedel-Crafts reactions.
Agreed. Most undergraduate organic chemistry texts come with a big disclaimer that Friedel-Crafts reactions work poorly on deactivated rings. I would love to see a link or reference for the use of nitrobenzene as a solvent for FC reactions. It would really solidify this answer.More
The nitro group is so deactivating that yields are really poor for Friedel-Crafts reactions with nitrobenzene; not even the meta-substituted product is found in good yield. In fact, nitrobenzene is actually used as a solvent in Friedel-Crafts reactions.
The nitro group is so deactivating that yields are really poor for Friedel-Crafts reactions with nitrobenzene; not even the meta-substituted product is found in good yield. In fact, nitrobenzene is actually used as a solvent in Friedel-Crafts reactions.
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