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Why sodium cyanoborohydride reactivity depends on pH?
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King Hailu
Why sodium cyanoborohydride reactivity depends on pH?
sodium cyanoborhydride 's selectivity is achieved at mild basic solutions (pH= 7-10). In acidic solutions , it is not stable forming very toxic gas of HCN
sodium cyanoborhydride 's selectivity is achieved at mild basic solutions (pH= 7-10). In acidic solutions , it is not stable forming very toxic gas of HCN
Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH. Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH. Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH. Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH. Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
sodium cyanoborhydride 's selectivity is achieved at mild basic solutions (pH= 7-10). In acidic solutions , it is not stable forming very toxic gas of HCN
sodium cyanoborhydride 's selectivity is achieved at mild basic solutions (pH= 7-10). In acidic solutions , it is not stable forming very toxic gas of HCN
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Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH.
Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH.
Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
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Acid destabilizes the sodium cyanoborohydride which results in an activated state for kinetics and equilibrium.
Acid destabilizes the sodium cyanoborohydride which results in an activated state for kinetics and equilibrium.
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Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH.
Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
Acidic conditions are required for the reaction to occur. Selectivity for reductive aminations is more of a happy coincidence. The formation of iminium ions is favoured around pH 6, and iminium ions reduce much faster than ketones at that pH.
Borch et al J. Am. Chem. Soc., 1971, 93 (12), pp 2897–2904
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In slightly acidic conditions it releases HCN and also the hydride required for the reaction
In slightly acidic conditions it releases HCN and also the hydride required for the reaction
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