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Why use sulphuric acid in preparation of aspirin?
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Lakshanna Yogarathnam
Why use sulphuric acid in preparation of aspirin?
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end,
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end,
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end so it is just a catalyst. Here is a reaction scheme done using phosphoric acid but the mechanism would be the same with sulfuric acid.
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end so it is just a catalyst. Here is a reaction scheme done using phosphoric acid but the mechanism would be the same with sulfuric acid.
You could make aspirin from salicylic acid and acetic acid, using sulfuric acid as the catalyst. Without it, the reaction would not proceed at a useful rate.
But you can also make aspirin using acetyl chloride or acetic anhydride rather than acetic acid. In these reactions, sulfuric acid is not needed to catalyze the reaction.
You could make aspirin from salicylic acid and acetic acid, using sulfuric acid as the catalyst. Without it, the reaction would not proceed at a useful rate.
But you can also make aspirin using acetyl chloride or acetic anhydride rather than acetic acid. In these reactions, sulfuric acid is not needed to catalyze the reaction.
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end,
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end,
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You are most likely preparing Aspirin from salicylic acid and acetic anhydride.
This esterification reaction is catalysed with small amounts of a strong acid. (sulfuric acid in this case)
If you add more than catalytic amounts, the sulfuric acid itself would hydrolyse the aspirin back to salicylic acid and acetic acid.
If you were to add very large amounts of sulfuric acid you might even sulfonate acetic anhydride to sulfoacetic acid.
You are most likely preparing Aspirin from salicylic acid and acetic anhydride.
This esterification reaction is catalysed with small amounts of a strong acid. (sulfuric acid in this case)
If you add more than catalytic amounts, the sulfuric acid itself would hydrolyse the aspirin back to salicylic acid and acetic acid.
If you were to add very large amounts of sulfuric acid you might even sulfonate acetic anhydride to sulfoacetic acid.
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The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end so it is just a catalyst. Here is a reaction scheme done using phosphoric acid but the mechanism would be the same with sulfuric acid.
The acid serves to protonate one double bonded oxygen on the acetic anhydride this makes the reaction with the salicylic acid faster. The proton is returned to the acid in the end so it is just a catalyst. Here is a reaction scheme done using phosphoric acid but the mechanism would be the same with sulfuric acid.
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Depends on how you were running the reaction.
You could make aspirin from salicylic acid and acetic acid, using sulfuric acid as the catalyst. Without it, the reaction would not proceed at a useful rate.
But you can also make aspirin using acetyl chloride or acetic anhydride rather than acetic acid. In these reactions, sulfuric acid is not needed to catalyze the reaction.
Depends on how you were running the reaction.
You could make aspirin from salicylic acid and acetic acid, using sulfuric acid as the catalyst. Without it, the reaction would not proceed at a useful rate.
But you can also make aspirin using acetyl chloride or acetic anhydride rather than acetic acid. In these reactions, sulfuric acid is not needed to catalyze the reaction.
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Sulphuric acid is used as catalyst for the reaction between salicylic acid and acetic acid to form acetylsalicylic acid/ asprin.
Sulphuric acid is used as catalyst for the reaction between salicylic acid and acetic acid to form acetylsalicylic acid/ asprin.
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Salicyclic acid reacts with acetic anhydride under acidic conditions to form acetylsalicylic acid (Aspirin) and acetic acid (Acid catalyzed reaction).
The functions are
Salicyclic acid, acetic anhydride - reagents
Sulphuric acid - catalyst
The reaction being
Salicyclic acid reacts with acetic anhydride under acidic conditions to form acetylsalicylic acid (Aspirin) and acetic acid (Acid catalyzed reaction).
The functions are
Salicyclic acid, acetic anhydride - reagents
Sulphuric acid - catalyst
The reaction being
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Sulphuric acid is used as the catalyst.
The sulphuric acid is not used in the reaction, it is just used as an acid catalyst of the esterification process.
See: mechanism for the esterification reaction
Sulphuric acid is used as the catalyst.
The sulphuric acid is not used in the reaction, it is just used as an acid catalyst of the esterification process.
See: mechanism for the esterification reaction
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It is the go-to catalytic acid. HCl is volatile, HNO3 is a powerful oxidizing and nitrating agent. Hard to beat sulfuric (But options do exist).
It is the go-to catalytic acid. HCl is volatile, HNO3 is a powerful oxidizing and nitrating agent. Hard to beat sulfuric (But options do exist).
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