Home > Community > Acetophenone synthesis without Friedel-Crafts
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Loren McCune

Acetophenone synthesis without Friedel-Crafts

Angela Shingler  Follow
That looks like a modification of friedel crafts.

What about Grignard reaction?

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Bruce Thomson  Follow
Grignard?

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Brandon Ross  Follow
I assume this is for a class?
What section are you currently covering?

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Dimitra Tsiovolou  Follow
Indeed, Alkenes, Alkynes and arenes.

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Liz O'Callaghan  Follow
My point is you stated in your first post that you need a route without F-C acylation.

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Owen Buss  Follow
I didn't realize that was a F-C acylation.

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Austin Bugden  Follow
Quote from:
What about with Acetic anhydride and Aluminium chloride, would that work?

That's Friedel-Crafts acylation.

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David Vanderschel  Follow
We can prepare acetophenone in vapour phase using zeolites as catalyst and aceticanhydride as acylating agent.

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Angel Vasquez  Follow
Hint, can you make the benzene ring into a better nucleophile, something that might add to an aldehyde or ketone?

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David Shobe  Follow
Quote from:
Indeed, Alkenes, Alkynes and arenes.

DO you know how to convert any of these into a ketone?

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Andrew McGregor  Follow
Right! Would this Friedel-Crafts acylation works too if we had let's say a bromobenzene instead of a benzene, or in this case, there are other factors a take into account?

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Dave LaFrenere  Follow
What about with Acetic anhydride and Aluminium chloride, would that work?

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Courtney Villeda  Follow
I only know some particulars transformation of Alkenes into ketone, like Friedel-Crafts or Ozonolysis.

In order to make the benzene a better nucleophile, I guess it should loss some H, but I'm not sure how.

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