That could work. I have a few ideas but can you tell us more detail about the method/conditions you are using? You are wanting to form the salt as the reaction proceeds rather than after completed?
That could work. I have a few ideas but can you tell us more detail about the method/conditions you are using? You are wanting to form the salt as the reaction proceeds rather than after completed?
So what it is it green! You can always re-cycle the chloroform! There is no green chemistry. If the reaction works well use it, to hell with the greenness of the process.
So what it is it green! You can always re-cycle the chloroform! There is no green chemistry. If the reaction works well use it, to hell with the greenness of the process.
I reduce substituted pyridines to piperidines using PtO2 as the catalyst under 3 bars pressure of Hydrogen gas. I normally do it in ethanol/Chloroform with 10/1 ratio and when the reaction is complete I just filter and evaporate to get the HCl salt of the piperidine. It does work but it's not green because I use Chloroform in a big excess.
I reduce substituted pyridines to piperidines using PtO2 as the catalyst under 3 bars pressure of Hydrogen gas. I normally do it in ethanol/Chloroform with 10/1 ratio and when the reaction is complete I just filter and evaporate to get the HCl salt of the piperidine. It does work but it's not green because I use Chloroform in a big excess.
I have a few ideas but can you tell us more detail about the method/conditions you are using? You are wanting to form the salt as the reaction proceeds rather than after completed?
I have a few ideas but can you tell us more detail about the method/conditions you are using? You are wanting to form the salt as the reaction proceeds rather than after completed?
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There is no green chemistry.
If the reaction works well use it, to hell with the greenness of the process.
There is no green chemistry.
If the reaction works well use it, to hell with the greenness of the process.
More
VOTE
More
VOTE