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Appel reaction CBR4 PPH3 does not have a product situation
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Miracle Jumbo
Appel reaction CBR4 PPH3 does not have a product situation
1. Tetrarine is not colorful. 2. Threezylpines are not pure, or have deteriorated, maybe this is an important factor that affects your reaction. 3. I think the substrate and tetrazide are added first, and then add the solution of tritenophenylpines, and the reaction temperature is low at room temperature.There is also the choice of solvents that cannot dissolve tritenophyl oxygen, because its generation is the driving force for reaction to continue.
1. Tetrarine is not colorful. 2. Threezylpines are not pure, or have deteriorated, maybe this is an important factor that affects your reaction. 3. I think the substrate and tetrazide are added first, and then add the solution of tritenophenylpines, and the reaction temperature is low at room temperature.There is also the choice of solvents that cannot dissolve tritenophyl oxygen, because its generation is the driving force for reaction to continue.
I have done a similar reaction. This bromine method is relatively weak. I am a mellastin and raw materials in the dichloromethane, and then add a trioxyl solid.Later, because it was not easy to separate the product, it was changed to bromine!
I have done a similar reaction. This bromine method is relatively weak. I am a mellastin and raw materials in the dichloromethane, and then add a trioxyl solid.Later, because it was not easy to separate the product, it was changed to bromine!
I usually use DCM to do solvents, dissolve the raw material and TPP (triangular phosphorus), and then add BBR3 in batches under the ice bath (I think the order of the feeding is nothing to do, because TPP has to react with CBR4 to react with hydroxyl).Room temperature reaction.
1, CBR4 is not colorful in ultraviolet lights.After a long time in the iodine cylinder, there will be a very shallow point, and the polarity is very small (sometimes it is not visible). 2, TPP will be oxidized to TPO (triangular oxidative phosphorus) over a long time. I do n’t know what your unfolding agent is. If you use a big polar running board, your point should be TPO. 3, you can take the TPO reagent as a standard product.TPP and excessive CBR4 or HCBR3 reaction can generate Ye Lide salt (great polarity), which may be the one under you.
I usually use DCM to do solvents, dissolve the raw material and TPP (triangular phosphorus), and then add BBR3 in batches under the ice bath (I think the order of the feeding is nothing to do, because TPP has to react with CBR4 to react with hydroxyl).Room temperature reaction.
1, CBR4 is not colorful in ultraviolet lights.After a long time in the iodine cylinder, there will be a very shallow point, and the polarity is very small (sometimes it is not visible). 2, TPP will be oxidized to TPO (triangular oxidative phosphorus) over a long time. I do n’t know what your unfolding agent is. If you use a big polar running board, your point should be TPO. 3, you can take the TPO reagent as a standard product.TPP and excessive CBR4 or HCBR3 reaction can generate Ye Lide salt (great polarity), which may be the one under you.
2. Threezylpines are not pure, or have deteriorated, maybe this is an important factor that affects your reaction.
3. I think the substrate and tetrazide are added first, and then add the solution of tritenophenylpines, and the reaction temperature is low at room temperature.There is also the choice of solvents that cannot dissolve tritenophyl oxygen, because its generation is the driving force for reaction to continue.
2. Threezylpines are not pure, or have deteriorated, maybe this is an important factor that affects your reaction.
3. I think the substrate and tetrazide are added first, and then add the solution of tritenophenylpines, and the reaction temperature is low at room temperature.There is also the choice of solvents that cannot dissolve tritenophyl oxygen, because its generation is the driving force for reaction to continue.
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1, CBR4 is not colorful in ultraviolet lights.After a long time in the iodine cylinder, there will be a very shallow point, and the polarity is very small (sometimes it is not visible).
2, TPP will be oxidized to TPO (triangular oxidative phosphorus) over a long time. I do n’t know what your unfolding agent is. If you use a big polar running board, your point should be TPO.
3, you can take the TPO reagent as a standard product.TPP and excessive CBR4 or HCBR3 reaction can generate Ye Lide salt (great polarity), which may be the one under you.
1, CBR4 is not colorful in ultraviolet lights.After a long time in the iodine cylinder, there will be a very shallow point, and the polarity is very small (sometimes it is not visible).
2, TPP will be oxidized to TPO (triangular oxidative phosphorus) over a long time. I do n’t know what your unfolding agent is. If you use a big polar running board, your point should be TPO.
3, you can take the TPO reagent as a standard product.TPP and excessive CBR4 or HCBR3 reaction can generate Ye Lide salt (great polarity), which may be the one under you.
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