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Are Friedel Crafts Acylation ortho driven?
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Jay T Arnott
Are Friedel Crafts Acylation ortho driven?
The primary reason ortho/para vs meta substituion occurs is not steric hinderence. Why do you say that ortho and para are more stable in EAS conditions? What does that even mean? There is another major factor in this reaction you are leaving out. What do you think it is?
The primary reason ortho/para vs meta substituion occurs is not steric hinderence. Why do you say that ortho and para are more stable in EAS conditions? What does that even mean? There is another major factor in this reaction you are leaving out. What do you think it is?
While I understand why para and ortho are more stable in EAS reactions, I don't understand why ortho seems to be the go to positions unless there's some crazy amount of steric hindrance. For example, when I was practicing friedel crafts acylation, almost all of them assumed that the electrophile would attach at the ortho position. Can someone clarify this for me?
Thank you!
Just to clarify your question: Are you asking about relative amounts of ortho vs para when the benzene ring is substituted with an O/P director? For example acylation products of phenol or toluene?
Also, a better way to phrase your initial statement would be to reference factors in the mechanism, especially the rate limiting step of the mechanism. Your phrasing was ambiguous, as Wildfyr pointed out.
While I understand why para and ortho are more stable in EAS reactions, I don't understand why ortho seems to be the go to positions unless there's some crazy amount of steric hindrance. For example, when I was practicing friedel crafts acylation, almost all of them assumed that the electrophile would attach at the ortho position. Can someone clarify this for me?
Thank you!
Just to clarify your question: Are you asking about relative amounts of ortho vs para when the benzene ring is substituted with an O/P director? For example acylation products of phenol or toluene?
Also, a better way to phrase your initial statement would be to reference factors in the mechanism, especially the rate limiting step of the mechanism. Your phrasing was ambiguous, as Wildfyr pointed out.
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Just to clarify your question: Are you asking about relative amounts of ortho vs para when the benzene ring is substituted with an O/P director? For example acylation products of phenol or toluene?
Also, a better way to phrase your initial statement would be to reference factors in the mechanism, especially the rate limiting step of the mechanism. Your phrasing was ambiguous, as Wildfyr pointed out.
Just to clarify your question: Are you asking about relative amounts of ortho vs para when the benzene ring is substituted with an O/P director? For example acylation products of phenol or toluene?
Also, a better way to phrase your initial statement would be to reference factors in the mechanism, especially the rate limiting step of the mechanism. Your phrasing was ambiguous, as Wildfyr pointed out.
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VOTE