I know the op didn't actually ask this but what about hydrogenolysis of benzyl ethers vs hydrogenation of nitriles? can a nitrile be hydrogenated selectively?
I know the op didn't actually ask this but what about hydrogenolysis of benzyl ethers vs hydrogenation of nitriles? can a nitrile be hydrogenated selectively?
If memory serves, reaction enthalpies are about 550 kJ/mol for nitro to amine, about 300 kJ/mol for alkyne (double reduction to alkane), about 150 kJ/mol for alkene, and about 70 kJ/mol for carbonyls.
You can hydrogenate alkenes selectively over ketones with Pt or Pd and H2. Some examples show alkenes and nitro groups both hydrogenated under these conditions.
Wilkinsons Catalyst in THF/t-BuOH will reduce the alkene but not the nitro. J. Org. Chem. 2002, 67 (9) 3163-3164
If memory serves, reaction enthalpies are about 550 kJ/mol for nitro to amine, about 300 kJ/mol for alkyne (double reduction to alkane), about 150 kJ/mol for alkene, and about 70 kJ/mol for carbonyls.
You can hydrogenate alkenes selectively over ketones with Pt or Pd and H2. Some examples show alkenes and nitro groups both hydrogenated under these conditions.
Wilkinsons Catalyst in THF/t-BuOH will reduce the alkene but not the nitro. J. Org. Chem. 2002, 67 (9) 3163-3164
This depends on how you define reactivity. The order you list nitro>alkyne>alkene>carbonyl tracks the reaction enthalpies: nitro is the most exothermic, carbonyl is the least.
But reactivity could also refer to the rate of the reaction, and this might be different depending on the catalyst that is used.
This depends on how you define reactivity. The order you list nitro>alkyne>alkene>carbonyl tracks the reaction enthalpies: nitro is the most exothermic, carbonyl is the least.
But reactivity could also refer to the rate of the reaction, and this might be different depending on the catalyst that is used.
1) Pd/C
2)Pt
With palladium is the correct order?
My doubt is about nitro group vs C=C hydrogenation
Thx
1) Pd/C
2)Pt
With palladium is the correct order?
My doubt is about nitro group vs C=C hydrogenation
Thx
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You can hydrogenate alkenes selectively over ketones with Pt or Pd and H2. Some examples show alkenes and nitro groups both hydrogenated under these conditions.
Wilkinsons Catalyst in THF/t-BuOH will reduce the alkene but not the nitro. J. Org. Chem. 2002, 67 (9) 3163-3164
You can hydrogenate alkenes selectively over ketones with Pt or Pd and H2. Some examples show alkenes and nitro groups both hydrogenated under these conditions.
Wilkinsons Catalyst in THF/t-BuOH will reduce the alkene but not the nitro. J. Org. Chem. 2002, 67 (9) 3163-3164
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But reactivity could also refer to the rate of the reaction, and this might be different depending on the catalyst that is used.
But reactivity could also refer to the rate of the reaction, and this might be different depending on the catalyst that is used.
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