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Elimination reaction with potassium tert butoxide.
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Kainat Ahmed
Elimination reaction with potassium tert butoxide.
Hey Acadasol, in case cooling it further doesn't work, perhaps you could try sodium methoxide? If you have a bit of dry methanol and some sodium you can do the elimination. Of course, lower temps should help to avoid cleaving that amide.
Hey Acadasol, in case cooling it further doesn't work, perhaps you could try sodium methoxide? If you have a bit of dry methanol and some sodium you can do the elimination. Of course, lower temps should help to avoid cleaving that amide.
Have you already tried running the reaction? As long as there is no water present or tBuOH as solvent I don't really think it's a problem? If it does happen try running the reaction at lower temperatures.
Have you already tried running the reaction? As long as there is no water present or tBuOH as solvent I don't really think it's a problem? If it does happen try running the reaction at lower temperatures.
I know its not the answer you wanted but why not eliminate 1st and then do the acylation of nitrogen? I cant think of way of doing that without something happening to that ester bond. Maybe using non-nucoleophilic base?
That sounds good but the nucleophilic nitrogen will cyclize if it were without the acyl group. The cyclization has been reported already.
I know its not the answer you wanted but why not eliminate 1st and then do the acylation of nitrogen? I cant think of way of doing that without something happening to that ester bond. Maybe using non-nucoleophilic base?
That sounds good but the nucleophilic nitrogen will cyclize if it were without the acyl group. The cyclization has been reported already.
I know its not the answer you wanted but why not eliminate 1st and then do the acylation of nitrogen? I cant think of way of doing that without something happening to that ester bond. Maybe using non-nucoleophilic base?
I know its not the answer you wanted but why not eliminate 1st and then do the acylation of nitrogen? I cant think of way of doing that without something happening to that ester bond. Maybe using non-nucoleophilic base?
Have you already tried running the reaction? As long as there is no water present or tBuOH as solvent I don't really think it's a problem? If it does happen try running the reaction at lower temperatures.
I actually maintained the reaction at -40 degree Celcius and moisture free to the best of my knowledge. Do you think bringing the temperature further down is going to help? Thanks!
Have you already tried running the reaction? As long as there is no water present or tBuOH as solvent I don't really think it's a problem? If it does happen try running the reaction at lower temperatures.
I actually maintained the reaction at -40 degree Celcius and moisture free to the best of my knowledge. Do you think bringing the temperature further down is going to help? Thanks!
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If it does happen try running the reaction at lower temperatures.
If it does happen try running the reaction at lower temperatures.
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That sounds good but the nucleophilic nitrogen will cyclize if it were without the acyl group. The cyclization has been reported already.
That sounds good but the nucleophilic nitrogen will cyclize if it were without the acyl group. The cyclization has been reported already.
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I actually maintained the reaction at -40 degree Celcius and moisture free to the best of my knowledge. Do you think bringing the temperature further down is going to help? Thanks!
I actually maintained the reaction at -40 degree Celcius and moisture free to the best of my knowledge. Do you think bringing the temperature further down is going to help? Thanks!
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VOTE