How to improve suzuki's reaction rate?

Your operation is really no problem, it is recommended that you change the carbonate

The operation is not a problem, it is recommended to increase the reaction temperature, increase the proportion of water (DME-H2O 4: 1), and the reaction temperature is 100oc.

Your reaction is a reaction site, and the amount of borate is up to two equivalents. In addition, it is recommended that the potassium carbonate is 10 equivalents, the amount of solvent water can also increase properly, and the SUZUKI general product price is not bad.

Seeing your description is not a problem, sometimes there may be accidental factors in accidents ~

Phenolic acid replacement conditions can generally be improved, it is relatively difficult, it is more difficult, it is recommended to change the tin reagent, it has been done before, the yield is not high, and the raw material consumption is not finished. Personal speculation is a Palladium reagent (only personal view, \"Do not spray)

Your reaction is actually two problems, one is temperature.The other is that your oxygen operation
temperature can be changed by changing the solvent, DMF H2O system 100 ° C
oxygenless is also very important

1. The solvent is exchanged to dioxane and water 5: 1, temperature 80-100 degrees.
2. Catalyst transposition of 1,1'-bis (di-tert-butylphosphine) diomorite dichlorpled palladium, to be used with K3PO4.CAS: 95408-45-0, but the price is high.
3. Microwave response to solve problems.

I have a literature report that if it is necessary to increase the yield, it will be high in the polar solvent DMSO or DMF yield.
There is also a bit of polarity that will not be triphenolate.

Phenolic acid replacement conditions can generally be improved, it is relatively difficult, it is more difficult, it is recommended to change the tin reagent, it has been done before, the yield is not high, and the raw material consumption is not finished. Personal speculation is a Palladium reagent (only personal view, \"Do not spray)

Personally think this base has problems, try potassium phosphate

Your reaction is a reaction site, and the amount of borate is up to two equivalents. In addition, it is recommended that the potassium carbonate is 10 equivalents, the amount of solvent water can also increase properly, and the SUZUKI general product price is not bad.

Seeing your description is not a problem, sometimes there may be accidental factors in accidents ~

I have a literature report that if it is necessary to increase the yield, it will be high in the polar solvent DMSO or DMF yield.
There is also a bit of polarity that will not be triphenolate.

Your reaction is actually two problems, one is temperature.The other is that your oxygen operation
temperature can be changed by changing the solvent, DMF H2O system 100 ° C
oxygenless is also very important

The operation is not a problem, it is recommended to increase the reaction temperature, increase the proportion of water (DME-H2O 4: 1), and the reaction temperature is 100oc.

1. The solvent is exchanged to dioxane and water 5: 1, temperature 80-100 degrees.
2. Catalyst transposition of 1,1'-bis (di-tert-butylphosphine) diomorite dichlorpled palladium, to be used with K3PO4.CAS: 95408-45-0, but the price is high.
3. Microwave response to solve problems.

Your operation is really no problem, it is recommended that you change the carbonate

Personally think this base has problems, try potassium phosphate