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+ Amino acids
+ Solid phase extraction
+ High-performance liquid chromatography
+ Peaks
+ Salts
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MaryBeth VanderMeulen

How to remove salts from a sample containing amino acids for HPLC...

Azizi Gill  Follow

Freja Karlsen BioRad spin columns are size exclusion, so your amino acids should be removed with salts, due to the size. Maybe you can consider by affinity. https://www.thermofisher.com/order/catalog/product/89879
Or you can ask directly to Amos Heckendorf sales@nestgrp.biz from NestGroup https://www.nestgrp.com/protocols/protocol.shtml#deterg
He is very helpful!

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Brian White  Follow

Dear Freja
Why did you think the impurities were due to salt? It is not possible to give an answer to your question without knowing the details of the analysis method apllied.

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Olivia (Gloria)  Follow

Also you can try liquid-liquid extraction technique to purify the sample.

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Bob Johnson  Follow

BioSpin columns from BioRad, Amicon filter from Merck Millipore or HiPPR™ Detergent Removal Spin Column Kit

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David Borgstrom  Follow

Thaís Pedrete Thank you. It is very helpful.

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Aphotic Sapian  Follow

Thaís Pedrete thanks for the recommendations.

I have looked at the different Bio-spin columns from Biorad and it seems there are several types. Which one can you specifically recommend for purification of amino acids prior to HPLC analysis?



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