I think this is probably steric. You have to be careful with mesylates, especially with the choice of base. I have often experienced that the chloride ion of the amine base displaces the mesylate and you end up with a halide!
I think this is probably steric. You have to be careful with mesylates, especially with the choice of base. I have often experienced that the chloride ion of the amine base displaces the mesylate and you end up with a halide!
That is great to keep in mind. I should say this is all theoretical to me. These are from past homeworks in a class I am to take this semester. Just trying to get ahead. I am realizing that I need help with my theory.
This is the next step in the synthetic scheme. I have to think about this some more, but how is a 5 membered ring more energetically favorable than a 6?
That is great to keep in mind. I should say this is all theoretical to me. These are from past homeworks in a class I am to take this semester. Just trying to get ahead. I am realizing that I need help with my theory.
This is the next step in the synthetic scheme. I have to think about this some more, but how is a 5 membered ring more energetically favorable than a 6?
From what I know saturated 5 membered are more stable than saturated 6 membered and unsaturated 6 membered are more stable than unsaturated 5 membered because of ring strain.
From what I know saturated 5 membered are more stable than saturated 6 membered and unsaturated 6 membered are more stable than unsaturated 5 membered because of ring strain.
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This is the next step in the synthetic scheme. I have to think about this some more, but how is a 5 membered ring more energetically favorable than a 6?
This is the next step in the synthetic scheme. I have to think about this some more, but how is a 5 membered ring more energetically favorable than a 6?
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