N methylation conditions

The activity of iodine methane is very good, you add more, then prolong the reaction time at low temperature, remember to open condensation.

Look at the mother structure, if lively, the raw material is iodide methane reflux, the reaction is taken for a period of time, the liquid base adjustment pH

One step directly methylation, you try DMF for solvent, 5 equivalents of methane, 2 equivalents of potassium carbonate. Try this condition
iodine methane, and easy to volatilize, pay attention to protection, you can consider extended firstThe reaction time is really no longer heating

Does the microwave tried?I have recently understood methyl, iodide, potassium carbonate, and DMF for solvent microwave conditions.

If there is no other reaction site, NaH can be used to react with the substrate in THF, and an excess iodomethane closed environment is added at low temperatures

If there is no potassium carbonate, try to change the carbonate, and the temperature is ok.

It can be reacted with a sealing tube so that the problem of temperature is solved and does not need to reflow.

Is it possible to reduce amine?