Hydrogen peroxide is so slow, needs heating and long reaction time when you have stericaly hindered amine. M-CPBA is more difficult to remove, needs chromatography.
Hydrogen peroxide is so slow, needs heating and long reaction time when you have stericaly hindered amine. M-CPBA is more difficult to remove, needs chromatography.
Great! Thank you. There is one exampel in the reference where they use peracetic acid and isolate the free base, thats all I wanted. I give you a "Mole snack" chenbeier.
Great! Thank you. There is one exampel in the reference where they use peracetic acid and isolate the free base, thats all I wanted. I give you a "Mole snack" chenbeier.
Then its probably no problem with m-CPBA. Peracetic acid is easie to messure with syringe, reaction is done in 2min in my case. Thanks for the reference wildfyr, I give you a mole snack. In my case I make N-oxide wich is very polar, partially water-soluble så I use DCM, the salt of benzoic acid could be soluble in in DCM, at least partially. In the referance they make epoxide.
Then its probably no problem with m-CPBA. Peracetic acid is easie to messure with syringe, reaction is done in 2min in my case. Thanks for the reference wildfyr, I give you a mole snack. In my case I make N-oxide wich is very polar, partially water-soluble så I use DCM, the salt of benzoic acid could be soluble in in DCM, at least partially. In the referance they make epoxide.
M-CPBA is more difficult to remove, needs chromatography.
M-CPBA is more difficult to remove, needs chromatography.
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It is a old german paper.
At chapter 1.4.1 Peressigsäure peracetic acid is decribed for the oxidation of amins:
https://books.google.de/books?id=1TOGAwAAQBAJ&pg=PA416&lpg=PA416&dq=aminoxide+peressigs%C3%A4ure&source=bl&ots=xPV2HkfSk3&sig=ACfU3U2KxxXP129tZ2zHQ4hxUVqpgQDgAw&hl=de&sa=X&ved=2ahUKEwjehIm13vXhAhUSqaQKHZtND2YQ6AEwCXoECAkQAQ#v=onepage&q=aminoxide%20peressigs%C3%A4ure&f=false
It is a old german paper.
At chapter 1.4.1 Peressigsäure peracetic acid is decribed for the oxidation of amins:
https://books.google.de/books?id=1TOGAwAAQBAJ&pg=PA416&lpg=PA416&dq=aminoxide+peressigs%C3%A4ure&source=bl&ots=xPV2HkfSk3&sig=ACfU3U2KxxXP129tZ2zHQ4hxUVqpgQDgAw&hl=de&sa=X&ved=2ahUKEwjehIm13vXhAhUSqaQKHZtND2YQ6AEwCXoECAkQAQ#v=onepage&q=aminoxide%20peressigs%C3%A4ure&f=false
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https://www.odinity.com/epoxidation-of-geraniol/
Peracetic acid, is volatile, somewhat more dangerous, and less reactive than mcpba
https://www.odinity.com/epoxidation-of-geraniol/
Peracetic acid, is volatile, somewhat more dangerous, and less reactive than mcpba
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In my case I make N-oxide wich is very polar, partially water-soluble så I use DCM, the salt of benzoic acid could be soluble in in DCM, at least partially. In the referance they make epoxide.
In my case I make N-oxide wich is very polar, partially water-soluble så I use DCM, the salt of benzoic acid could be soluble in in DCM, at least partially. In the referance they make epoxide.
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