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Reduction of Vanillin into Vanillyl Alcohol with Sodium Borohydride
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Lizzi Brown
Reduction of Vanillin into Vanillyl Alcohol with Sodium Borohydride
Why are you asking about something that has long been a known procedure? Even if there are two types of procedures, there is something behind it. The idea is for the reduction to take place in solution (why in solution - for the reaction to go fairly quickly; this is quite important in alcoholic solutions because alcohol breaks down NaBH4 - fortunately quite slowly). If we reduce the water-insoluble aldehyde or ketone, you must use a water-miscible solvent (the choice is small - methanol or ethanol) in such an amount that after adding NaBH4 in NaOH (why in NaOH - because NaBH4 is relatively stable in a strongly alkaline solution). In the case of vanillin, it can be dissolved in a solution of NaOH or alcohol. All this can be read in textbooks - sometimes between the lines, but it results from the knowledge already possessed by the reader.
Why are you asking about something that has long been a known procedure? Even if there are two types of procedures, there is something behind it. The idea is for the reduction to take place in solution (why in solution - for the reaction to go fairly quickly; this is quite important in alcoholic solutions because alcohol breaks down NaBH4 - fortunately quite slowly). If we reduce the water-insoluble aldehyde or ketone, you must use a water-miscible solvent (the choice is small - methanol or ethanol) in such an amount that after adding NaBH4 in NaOH (why in NaOH - because NaBH4 is relatively stable in a strongly alkaline solution). In the case of vanillin, it can be dissolved in a solution of NaOH or alcohol. All this can be read in textbooks - sometimes between the lines, but it results from the knowledge already possessed by the reader.
All this can be read in textbooks - sometimes between the lines, but it results from the knowledge already possessed by the reader.
All this can be read in textbooks - sometimes between the lines, but it results from the knowledge already possessed by the reader.
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