In my experience, there is one trick you can try to separate secondary and tertiary amines chemically, using reductive amination.
This trick will not only add chromophore to secondary amine, but also reduce the polarity of the molecule significantly. Both of them will help the seperation in column chromatography.
Since you have the problem solved, you may save this trick for next time.
Well, thank you for the trick! But, as I mentioned in the post, I am preparing ligands for metals. I would save it for other topics.
In my experience, there is one trick you can try to separate secondary and tertiary amines chemically, using reductive amination.
This trick will not only add chromophore to secondary amine, but also reduce the polarity of the molecule significantly. Both of them will help the seperation in column chromatography.
Since you have the problem solved, you may save this trick for next time.
Well, thank you for the trick! But, as I mentioned in the post, I am preparing ligands for metals. I would save it for other topics.
In my experience, there is one trick you can try to separate secondary and tertiary amines chemically, using reductive amination.
This trick will not only add chromophore to secondary amine, but also reduce the polarity of the molecule significantly. Both of them will help the seperation in column chromatography.
Since you have the problem solved, you may save this trick for next time.
In my experience, there is one trick you can try to separate secondary and tertiary amines chemically, using reductive amination.
This trick will not only add chromophore to secondary amine, but also reduce the polarity of the molecule significantly. Both of them will help the seperation in column chromatography.
Since you have the problem solved, you may save this trick for next time.
Thank you for the replies But, I figured out that N-Methylpiperazine has bp of 110~120 C, so I just dried it in the vacuum. And, as you stated to separate in basic condition, I had another trial with more base. It worked really well.
Thank you for the replies But, I figured out that N-Methylpiperazine has bp of 110~120 C, so I just dried it in the vacuum. And, as you stated to separate in basic condition, I had another trial with more base. It worked really well.
I would first try to recrystallize it, but this is a sometimes intractable problem. It's better to run reactions that minimize the amount of undesired amine via the setup and reagents.
I would first try to recrystallize it, but this is a sometimes intractable problem. It's better to run reactions that minimize the amount of undesired amine via the setup and reagents.
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Well, thank you for the trick! But, as I mentioned in the post, I am preparing ligands for metals. I would save it for other topics.
Well, thank you for the trick! But, as I mentioned in the post, I am preparing ligands for metals. I would save it for other topics.
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This trick will not only add chromophore to secondary amine, but also reduce the polarity of the molecule significantly. Both of them will help the seperation in column chromatography.
Since you have the problem solved, you may save this trick for next time.
This trick will not only add chromophore to secondary amine, but also reduce the polarity of the molecule significantly. Both of them will help the seperation in column chromatography.
Since you have the problem solved, you may save this trick for next time.
More
VOTE
But, I figured out that N-Methylpiperazine has bp of 110~120 C, so I just dried it in the vacuum.
And, as you stated to separate in basic condition, I had another trial with more base. It worked really well.
But, I figured out that N-Methylpiperazine has bp of 110~120 C, so I just dried it in the vacuum.
And, as you stated to separate in basic condition, I had another trial with more base. It worked really well.
More
VOTE
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Another option, is it low weight enough for one or both to be fractionally distilled? Even easier than a column.
Another option, is it low weight enough for one or both to be fractionally distilled? Even easier than a column.
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