The neutralization of amine hydrochloric acid is the most effective way to ionamide

The corpse has been steamed out, volatilization

Pay attention to nitrogen protection, carbon dioxide in the air and amine salt

Slowly add methanol sodium, suspend dichloromethane, stir for a period of time filter

Total amine hydrochloride TCM has solubility.It is better to use ammonia water, just disintegrate the layering after the dissolution