Selectivity is used when talking about the substrate, for example an enzyme can be more selective for D- sugars compared to L-sugars.
Specificity is used when talking about the product. For example an enzyme that only accepts a single compound could specifically hydroxylate the 2 position, even though there are be more positions that could be hydroxylated.
Selectivity is used when talking about the substrate, for example an enzyme can be more selective for D- sugars compared to L-sugars.
Specificity is used when talking about the product. For example an enzyme that only accepts a single compound could specifically hydroxylate the 2 position, even though there are be more positions that could be hydroxylated.
Specificity is the term used to define the selectivity of enzymes
for their substrates. The selective qualities of an enzyme are collectively recognized as its specificity.
Other texts have synonymised enzyme selectivity with substrate specificity:
The non-covalent forces through which substrates and other molecules bind to enzymes are similar in character to the forces
that dictate the conformations of the proteins themselves : Both involve van der Waals, electrostatic, hydrogen
bonding, and hydrophobic interactions.
Molecules that differ in shape or functional group distribution
from the substrate cannot productively bind to the
enzyme; that is, they cannot form enzyme–substrate complexes
that lead to the formation of products.
The extraordinary ability of an enzyme to catalyse only one particular reaction is a quality known as specificity.
Specificity means an enzyme acts only on a specific substance,
its substrate, invariably transforming it into a specific product. That is, an enzyme
binds only certain compounds, and then, only a specific reaction ensues.
Some enzymes show absolute specificity, catalyzing the transformation of only one
specific substrate to yield a unique product. Other enzymes carry out a particular
reaction but act on a class of compounds. For example, hexokinase (ATP-hexose-6-
phosphotransferase) will carry out the ATP-dependent phosphorylation of a number
of hexoses at the 6-position, including glucose.
Pioneering enzyme specificity studies at the turn of the 20th century
by the great organic chemist Emil Fischer led to the notion of an
enzyme resembling a “lock” and its particular substrate the “key.”
The specificity of an enzyme (the lock) for its substrate (the key) arises from their geometrically complementary shapes. This was later
modified to a more accurate induced fit hypothesis given the high
flexibility, conformationally dynamic properties of enzyme molecules.
References
Voet and Voet Biochemistry 4th ed: Introduction to Enzymes
Biochemistry Grisham & Garret How Can Enzymes Be So Specific?
Specificity is the term used to define the selectivity of enzymesfor their substrates. The selective qualities of an enzyme are collectively recognized as its specificity.
Other texts have synonymised enzyme selectivity with substrate specificity:
The non-covalent forces through which substrates and other molecules bind to enzymes are similar in character to the forcesthat dictate the conformations of the proteins themselves : Both involve van der Waals, electrostatic, hydrogenbonding, and hydrophobic interactions.Molecules that differ in shape or functional group distributionfrom the substrate cannot productively bind to theenzyme; that is, they cannot form enzyme–substrate complexesthat lead to the formation of products.
The extraordinary ability of an enzyme to catalyse only one particular reaction is a quality known as specificity.
Specificity means an enzyme acts only on a specific substance,its substrate, invariably transforming it into a specific product. That is, an enzymebinds only certain compounds, and then, only a specific reaction ensues.Some enzymes show absolute specificity, catalyzing the transformation of only onespecific substrate to yield a unique product. Other enzymes carry out a particularreaction but act on a class of compounds. For example, hexokinase (ATP-hexose-6-phosphotransferase) will carry out the ATP-dependent phosphorylation of a numberof hexoses at the 6-position, including glucose.
Pioneering enzyme specificity studies at the turn of the 20th centuryby the great organic chemist Emil Fischer led to the notion of anenzyme resembling a “lock” and its particular substrate the “key.”The specificity of an enzyme (the lock) for its substrate (the key) arises from their geometrically complementary shapes. This was latermodified to a more accurate induced fit hypothesis given the highflexibility, conformationally dynamic properties of enzyme molecules.
References
Voet and Voet Biochemistry 4th ed: Introduction to Enzymes
Biochemistry Grisham & Garret How Can Enzymes Be So Specific?
Selectivity is used when talking about the substrate, for example an enzyme can be more selective for D- sugars compared to L-sugars.
Specificity is used when talking about the product. For example an enzyme that only accepts a single compound could specifically hydroxylate the 2 position, even though there are be more positions that could be hydroxylated.
Selectivity is used when talking about the substrate, for example an enzyme can be more selective for D- sugars compared to L-sugars.
Specificity is used when talking about the product. For example an enzyme that only accepts a single compound could specifically hydroxylate the 2 position, even though there are be more positions that could be hydroxylated.
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VOTE
Specificity is the term used to define the selectivity of enzymes for their substrates. The selective qualities of an enzyme are collectively recognized as its specificity.
Other texts have synonymised enzyme selectivity with substrate specificity:
The extraordinary ability of an enzyme to catalyse only one particular reaction is a quality known as specificity.
Specificity means an enzyme acts only on a specific substance, its substrate, invariably transforming it into a specific product. That is, an enzyme binds only certain compounds, and then, only a specific reaction ensues. Some enzymes show absolute specificity, catalyzing the transformation of only one specific substrate to yield a unique product. Other enzymes carry out a particular reaction but act on a class of compounds. For example, hexokinase (ATP-hexose-6- phosphotransferase) will carry out the ATP-dependent phosphorylation of a number of hexoses at the 6-position, including glucose.
References
Specificity is the term used to define the selectivity of enzymesfor their substrates. The selective qualities of an enzyme are collectively recognized as its specificity.
Other texts have synonymised enzyme selectivity with substrate specificity:
The extraordinary ability of an enzyme to catalyse only one particular reaction is a quality known as specificity.
Specificity means an enzyme acts only on a specific substance,its substrate, invariably transforming it into a specific product. That is, an enzymebinds only certain compounds, and then, only a specific reaction ensues.Some enzymes show absolute specificity, catalyzing the transformation of only onespecific substrate to yield a unique product. Other enzymes carry out a particularreaction but act on a class of compounds. For example, hexokinase (ATP-hexose-6-phosphotransferase) will carry out the ATP-dependent phosphorylation of a numberof hexoses at the 6-position, including glucose.
References
More
VOTE