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How to convert human dose to animal dose?
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Mark Vernall
How to convert human dose to animal dose?
Venu, Yes you are right, you will have sum up of all the ingredients and convert it back to human dose (assuming that all the ingredients contains the active principles for the said indication)
Santosh, These calculations are taken from the FDA guideline on the estimation of the safe starting dose in human. In the guideline, the values are given to calculate the animal dose to human dose and I have used the same values to back calculate the human dose to animal dose. You can also use Ghosh book on the Experimental Pharmacology, (I believe) to derive the interspecies dose calculation and both the method will give you the same results. Srinivasan
Venu, Yes you are right, you will have sum up of all the ingredients and convert it back to human dose (assuming that all the ingredients contains the active principles for the said indication)
Santosh, These calculations are taken from the FDA guideline on the estimation of the safe starting dose in human. In the guideline, the values are given to calculate the animal dose to human dose and I have used the same values to back calculate the human dose to animal dose. You can also use Ghosh book on the Experimental Pharmacology, (I believe) to derive the interspecies dose calculation and both the method will give you the same results. Srinivasan
[Conversion from 60 Kg person to 150 g rat] Conversion using Km factor Animal dose (mg/kg) = 1500 mg/kg × (37/6) =1500 x 6.17 =9250 mg/kg = 9.25 g/kg in rats.
Where, 6=Km factor for rat ; 37= Km factor for human. or [Conversion from 70 kg person to 200 g rat] Conversion using Body weight Animal dose (mg/kg) = 1500 mg/kg × (70/0.200)^0.33 =1500 x [350]^0.33 =1500x 6.91 =10366.5 mg/kg = 10.366 g/kg in rats.
Where, 70 (70kg) =Body weight of human ; 0.2 (200 g)= Body weight of rat.
[Conversion from 60 Kg person to 150 g rat] Conversion using Km factor Animal dose (mg/kg) = 1500 mg/kg × (37/6) =1500 x 6.17 =9250 mg/kg = 9.25 g/kg in rats.
Where, 6=Km factor for rat ; 37= Km factor for human. or [Conversion from 70 kg person to 200 g rat] Conversion using Body weight Animal dose (mg/kg) = 1500 mg/kg × (70/0.200)^0.33 =1500 x [350]^0.33 =1500x 6.91 =10366.5 mg/kg = 10.366 g/kg in rats.
Where, 70 (70kg) =Body weight of human ; 0.2 (200 g)= Body weight of rat.
For which species do you want to convert the human dose? The way I convert the human dose to animal dose is based on the body surface area. Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3 Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4 Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6 Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1 Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
For which species do you want to convert the human dose? The way I convert the human dose to animal dose is based on the body surface area. Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3 Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4 Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6 Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1 Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3 Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4 Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6 Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1 Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3 Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4 Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6 Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1 Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
Please check, the following examples may help you to understand the conversion from Animals to HED and Vice versa.
Example. 1. Suppose effective dose in mice is 1000 mg/kg, and if we have to convert to human equivalent dose (HED). HED (mg/kg) = Animal dose (mg/kg)X (Km factor of animal /Km factor of humans) HED (mg/kg) = 1000 mg/kg × (3/37) = 81.1 mg/kg (4.866 g/day) in humans. Where, km factor for mice=3; km factor for human =37.
Note: HED (mg/kg) has to be multiplied by 60 kg --> Human dose mg/day.
Please check, the following examples may help you to understand the conversion from Animals to HED and Vice versa.
Example. 1. Suppose effective dose in mice is 1000 mg/kg, and if we have to convert to human equivalent dose (HED). HED (mg/kg) = Animal dose (mg/kg)X (Km factor of animal /Km factor of humans) HED (mg/kg) = 1000 mg/kg × (3/37) = 81.1 mg/kg (4.866 g/day) in humans. Where, km factor for mice=3; km factor for human =37.
Note: HED (mg/kg) has to be multiplied by 60 kg --> Human dose mg/day.
Venu,
Yes you are right, you will have sum up of all the ingredients and convert it back to human dose (assuming that all the ingredients contains the active principles for the said indication)
Santosh,
These calculations are taken from the FDA guideline on the estimation of the safe starting dose in human. In the guideline, the values are given to calculate the animal dose to human dose and I have used the same values to back calculate the human dose to animal dose. You can also use Ghosh book on the Experimental Pharmacology, (I believe) to derive the interspecies dose calculation and both the method will give you the same results.
Srinivasan
Venu,
Yes you are right, you will have sum up of all the ingredients and convert it back to human dose (assuming that all the ingredients contains the active principles for the said indication)
Santosh,
These calculations are taken from the FDA guideline on the estimation of the safe starting dose in human. In the guideline, the values are given to calculate the animal dose to human dose and I have used the same values to back calculate the human dose to animal dose. You can also use Ghosh book on the Experimental Pharmacology, (I believe) to derive the interspecies dose calculation and both the method will give you the same results.
Srinivasan
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https://images.app.goo.gl/Gbpj6ngBGTBJC8di7
https://images.app.goo.gl/Gbpj6ngBGTBJC8di7
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If a person weighing 70 kg is given a dose of 1.5 g / kg, what is the dose for a rat weighing 200 g?
If a person weighing 70 kg is given a dose of 1.5 g / kg, what is the dose for a rat weighing 200 g?
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Hello Uuganbayar Uuganaa Baatartsogt,
To answer you question,
[Conversion from 60 Kg person to 150 g rat]
Conversion using Km factor
Animal dose (mg/kg) = 1500 mg/kg × (37/6)
=1500 x 6.17
=9250 mg/kg = 9.25 g/kg in rats.
Where, 6=Km factor for rat ; 37= Km factor for human.
or
[Conversion from 70 kg person to 200 g rat]
Conversion using Body weight
Animal dose (mg/kg) = 1500 mg/kg × (70/0.200)^0.33
=1500 x [350]^0.33
=1500x 6.91
=10366.5 mg/kg = 10.366 g/kg in rats.
Where, 70 (70kg) =Body weight of human ; 0.2 (200 g)= Body weight of rat.
Also find the attached references
Hope this helps you.
Regards
Dr G L Vishwanath
Hello Uuganbayar Uuganaa Baatartsogt,
To answer you question,
[Conversion from 60 Kg person to 150 g rat]
Conversion using Km factor
Animal dose (mg/kg) = 1500 mg/kg × (37/6)
=1500 x 6.17
=9250 mg/kg = 9.25 g/kg in rats.
Where, 6=Km factor for rat ; 37= Km factor for human.
or
[Conversion from 70 kg person to 200 g rat]
Conversion using Body weight
Animal dose (mg/kg) = 1500 mg/kg × (70/0.200)^0.33
=1500 x [350]^0.33
=1500x 6.91
=10366.5 mg/kg = 10.366 g/kg in rats.
Where, 70 (70kg) =Body weight of human ; 0.2 (200 g)= Body weight of rat.
Also find the attached references
Hope this helps you.
Regards
Dr G L Vishwanath
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VOTE
For which species do you want to convert the human dose? The way I convert the human dose to animal dose is based on the body surface area.
Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3
Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4
Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6
Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1
Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
For which species do you want to convert the human dose? The way I convert the human dose to animal dose is based on the body surface area.
Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3
Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4
Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6
Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1
Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
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I have a question.
One Drug is A and other one is B. Now, LD50 of A drug is 1 mg/ kg bw...LD50 of B drug is 4mg/kg bw.....which drug is more Toxic than another one?
I have a question.
One Drug is A and other one is B. Now, LD50 of A drug is 1 mg/ kg bw...LD50 of B drug is 4mg/kg bw.....which drug is more Toxic than another one?
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@Tamanna Roy The smaller the LD50, the more toxic the drug is. So A is more toxic (the dose required to induce 50% of the toxicity is less than B)
@Tamanna Roy The smaller the LD50, the more toxic the drug is. So A is more toxic (the dose required to induce 50% of the toxicity is less than B)
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Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3
Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4
Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6
Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1
Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3
Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4
Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6
Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1
Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8
More
VOTE
Would you please tell me how to convert human dose to chick embryo dose per egg for in ovo injection?
Would you please tell me how to convert human dose to chick embryo dose per egg for in ovo injection?
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Useful article
Useful article
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Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3
Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3
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VOTE
Hi Venu,
Please check, the following examples may help you to understand the conversion from Animals to HED and Vice versa.
Example. 1.
Suppose effective dose in mice is 1000 mg/kg, and if we have to convert to human equivalent dose (HED).
HED (mg/kg) = Animal dose (mg/kg)X (Km factor of animal /Km factor of humans)
HED (mg/kg) = 1000 mg/kg × (3/37) = 81.1 mg/kg (4.866 g/day) in humans.
Where, km factor for mice=3; km factor for human =37.
Note: HED (mg/kg) has to be multiplied by 60 kg --> Human dose mg/day.
The conversion equation, Km values, BSA etc can be obtained from FDA document, please find the link below.
https://www.fda.gov/media/72309/download
Example 2. Suppose clinical effective dose is 200 mg/kg (Human dose/60kg---> Human dose mg/kg), and we need to convert it to dose for rats.
Animal dose (mg/kg) = 200 mg/kg × (37/6) = 1233 mg/kg in rats.
Where, km factor for mice=6; km factor for human =37.
Please refer these documents.
https://www.jkom.org/upload/31-3%2001%20[01-07].pdf
Article Dose translation from animal to human studies revisited
https://www.fda.gov/media/72309/download
Hi Venu,
Please check, the following examples may help you to understand the conversion from Animals to HED and Vice versa.
Example. 1.
Suppose effective dose in mice is 1000 mg/kg, and if we have to convert to human equivalent dose (HED).
HED (mg/kg) = Animal dose (mg/kg)X (Km factor of animal /Km factor of humans)
HED (mg/kg) = 1000 mg/kg × (3/37) = 81.1 mg/kg (4.866 g/day) in humans.
Where, km factor for mice=3; km factor for human =37.
Note: HED (mg/kg) has to be multiplied by 60 kg --> Human dose mg/day.
The conversion equation, Km values, BSA etc can be obtained from FDA document, please find the link below.
https://www.fda.gov/media/72309/download
Example 2. Suppose clinical effective dose is 200 mg/kg (Human dose/60kg---> Human dose mg/kg), and we need to convert it to dose for rats.
Animal dose (mg/kg) = 200 mg/kg × (37/6) = 1233 mg/kg in rats.
Where, km factor for mice=6; km factor for human =37.
Please refer these documents.
https://www.jkom.org/upload/31-3%2001%20[01-07].pdf
Article Dose translation from animal to human studies revisited
https://www.fda.gov/media/72309/download
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