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how to separate gamma-butyrolactone from N-methyl-2-pyrrolidone
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+ Biochemistry
+ Purification
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Linden Adkins, Ph.D.
how to separate gamma-butyrolactone from N-methyl-2-pyrrolidone
Cud [sic] a person wanting to separate these just emerse [sic] them into liquid nitro [sic] or any [sic] to get the desired chemical to freeze then filter off the unfrozen butyrolacton [sic]?
With liquid nitrogen this would not be possible because liquid nitrogen condenses/boils at -195 °C. It would freeze both the pyrrolidone and the lactone.
Cud [sic] a person wanting to separate these just emerse [sic] them into liquid nitro [sic] or any [sic] to get the desired chemical to freeze then filter off the unfrozen butyrolacton [sic]?
With liquid nitrogen this would not be possible because liquid nitrogen condenses/boils at -195 °C. It would freeze both the pyrrolidone and the lactone.
Im not sure which compound (both?) you need to recover. If you want to recover just the NMP, then you could probably separate it from the GBL by hydrolyzing the GLB with a strong base, for 4-hydroxybutyrate salts, and then doing a solvent extraction with chloroform or hexanes to separate the NMP from the GBL-derived salts. Then the NMP can be re-isolated by evaporation of the chloroform or hexanes.More
Well. Then say what would a person use to separate these two compounds that would not require distillation and adding of chemicals. Freezing the undesirable must be possible ?More
My answer originally said LN2 "freezes" but of course I meant "condenses". Im talking about the boiling point not the freezing point so I am editing my answer.More
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As Curt F. has already pointed out, liquid nitrogen is an overkill and won't help here.
With liquid nitrogen this would not be possible because liquid nitrogen condenses/boils at -195 °C. It would freeze both the pyrrolidone and the lactone.
With liquid nitrogen this would not be possible because liquid nitrogen condenses/boils at -195 °C. It would freeze both the pyrrolidone and the lactone.
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As Curt F. has already pointed out, liquid nitrogen is an overkill and won't help here.
You might want to try one of the following cooling mixtures - values are taken from (http://www.chemieunterricht.de/dc2/tip/08_98.htm):
to enrich NMP in ther solid fraction.
As Curt F. has already pointed out, liquid nitrogen is an overkill and won't help here.
You might want to try one of the following cooling mixtures - values are taken from (http://www.chemieunterricht.de/dc2/tip/08_98.htm):
to enrich NMP in ther solid fraction.
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