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Michele Cini

Plink error: --check-sex/--impute-sex requires at least one polymorphic X chromosome locus

David Fenderson  Follow

Without X chromosome variation, sex cannot be reliably determined from input genotypes.

The error is telling you that there are no polymorphic X chromosome loci in the provided data. Either your input files don't include any X chromosome information (this could happen due to the increased statistical challenges involved in X chromosome data), or all the X chromosome "variants" are invariant / homozygous.

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