Home >
Community >
Synthesis of phenoxyacetone from phenol
Upvote
22
Downvote
+ Biochemistry
+ Synthesis
Posted by
Justin Martinez
Synthesis of phenoxyacetone from phenol
Your suggested method seems excessively complicated. Substitution of chloroacetone with phenol under basic conditions should give O-alkylation in reasonably good yield. The phenol will be deprotonated and the nucleophilic phenoxide ion will then undergo an $S_N2$ reaction with the primary alkyl chloride.
Your suggested method seems excessively complicated. Substitution of chloroacetone with phenol under basic conditions should give O-alkylation in reasonably good yield. The phenol will be deprotonated and the nucleophilic phenoxide ion will then undergo an $S_N2$ reaction with the primary alkyl chloride.
Your suggested method seems excessively complicated. Substitution of chloroacetone with phenol under basic conditions should give O-alkylation in reasonably good yield. The phenol will be deprotonated and the nucleophilic phenoxide ion will then undergo an $S_N2$ reaction with the primary alkyl chloride.
Your suggested method seems excessively complicated. Substitution of chloroacetone with phenol under basic conditions should give O-alkylation in reasonably good yield. The phenol will be deprotonated and the nucleophilic phenoxide ion will then undergo an $S_N2$ reaction with the primary alkyl chloride.
More
VOTE