Hydrogenation all the way…. :) Use a balloon of hydrogen with your compound in ethyl acetate and Lindlar's catalyst. Leaves ketones and even most double bonds intact…. Also, SnCl2 would be a classic that is cheap, easy and rarely fails to perform.
Hydrogenation all the way…. :) Use a balloon of hydrogen with your compound in ethyl acetate and Lindlar's catalyst. Leaves ketones and even most double bonds intact…. Also, SnCl2 would be a classic that is cheap, easy and rarely fails to perform.
Dear Maiada, the simplest way might be to protect keto carbonyl via oxime, hydrazone or aminoguanidine derivative formation /you may use NH2OH.HCl, H2N-NH2 or H2N-NH-/C=NH/- NH2.H2SO4. If your compound is not solubile in water, use less polar solvent, e.g. ethanol or methanol prior to reaction with the above mentioned reagents Then you may reduce C-NO2 of the derivative using Fe powder/water solution of H2SO4. You might also use Zn/solution of H2SO4 reducing agent. Reduction should not be performed at elevated temperature, not to cause hydolysis of the prepared amino-derivative. I wonder wether Schulz-Tieman reduction /FeCl2 - HCl/ would not do for reduction of the nitro group. When reduction is over you shall have to separate your product and submitt it to acid hydrolysis at increased temperature to obtain your expected keto-amine moiety. Good luck, R.S.
Dear Maiada, the simplest way might be to protect keto carbonyl via oxime, hydrazone or aminoguanidine derivative formation /you may use NH2OH.HCl, H2N-NH2 or H2N-NH-/C=NH/- NH2.H2SO4. If your compound is not solubile in water, use less polar solvent, e.g. ethanol or methanol prior to reaction with the above mentioned reagents Then you may reduce C-NO2 of the derivative using Fe powder/water solution of H2SO4. You might also use Zn/solution of H2SO4 reducing agent. Reduction should not be performed at elevated temperature, not to cause hydolysis of the prepared amino-derivative. I wonder wether Schulz-Tieman reduction /FeCl2 - HCl/ would not do for reduction of the nitro group. When reduction is over you shall have to separate your product and submitt it to acid hydrolysis at increased temperature to obtain your expected keto-amine moiety. Good luck, R.S.
Sorry hydrogen it should be
Sorry hydrogen it should be
More
VOTE
SnCl2 http://www.alfa-chemistry.com/stannous-chloride-dihydrate-cas-10025-69-1-item-25338.htm
PtO2 http://www.alfa-chemistry.com/platinum-iv-oxide-cas-52785-06-5-item-25351.htm
Hope these reagents could help you.
SnCl2 http://www.alfa-chemistry.com/stannous-chloride-dihydrate-cas-10025-69-1-item-25338.htm
PtO2 http://www.alfa-chemistry.com/platinum-iv-oxide-cas-52785-06-5-item-25351.htm
Hope these reagents could help you.
More
VOTE
Hydrogenation all the way…. :) Use a balloon of hydrogen with your compound in ethyl acetate and Lindlar's catalyst. Leaves ketones and even most double bonds intact….
Also, SnCl2 would be a classic that is cheap, easy and rarely fails to perform.
Hydrogenation all the way…. :) Use a balloon of hydrogen with your compound in ethyl acetate and Lindlar's catalyst. Leaves ketones and even most double bonds intact….
Also, SnCl2 would be a classic that is cheap, easy and rarely fails to perform.
More
VOTE
Typical reducing agents include, Fe / H+, Sn / H+ or catalytic hydrogenation (e.g. H2 / Pd)
Typical reducing agents include, Fe / H+, Sn / H+ or catalytic hydrogenation (e.g. H2 / Pd)
More
VOTE
To reduce a nitro group to a primary amine but not reduce ketones, you can use Fe in HCl or H2/PtO2 catalyst.
To reduce a nitro group to a primary amine but not reduce ketones, you can use Fe in HCl or H2/PtO2 catalyst.
More
VOTE
Which condition help to reduce the cost, waste, environmentally friendly.
Your suggestions welcome.
Which condition help to reduce the cost, waste, environmentally friendly.
Your suggestions welcome.
More
VOTE
Dear Maiada,
the simplest way might be to protect keto carbonyl via oxime, hydrazone or aminoguanidine derivative formation /you may use NH2OH.HCl, H2N-NH2 or H2N-NH-/C=NH/- NH2.H2SO4. If your compound is not solubile in water, use less polar solvent, e.g. ethanol or methanol prior to reaction with the above mentioned reagents
Then you may reduce C-NO2 of the derivative using Fe powder/water solution of H2SO4. You might also use Zn/solution of H2SO4 reducing agent. Reduction should not be performed at elevated temperature, not to cause hydolysis of the prepared amino-derivative. I wonder wether Schulz-Tieman reduction /FeCl2 - HCl/ would not do for reduction of the nitro group.
When reduction is over you shall have to separate your product and submitt it to acid hydrolysis at increased temperature to obtain your expected keto-amine moiety.
Good luck,
R.S.
Dear Maiada,
the simplest way might be to protect keto carbonyl via oxime, hydrazone or aminoguanidine derivative formation /you may use NH2OH.HCl, H2N-NH2 or H2N-NH-/C=NH/- NH2.H2SO4. If your compound is not solubile in water, use less polar solvent, e.g. ethanol or methanol prior to reaction with the above mentioned reagents
Then you may reduce C-NO2 of the derivative using Fe powder/water solution of H2SO4. You might also use Zn/solution of H2SO4 reducing agent. Reduction should not be performed at elevated temperature, not to cause hydolysis of the prepared amino-derivative. I wonder wether Schulz-Tieman reduction /FeCl2 - HCl/ would not do for reduction of the nitro group.
When reduction is over you shall have to separate your product and submitt it to acid hydrolysis at increased temperature to obtain your expected keto-amine moiety.
Good luck,
R.S.
More
VOTE
To reduce a nitro group to a primary amine but not reduce ketones, you can use Fe in HCl or H2/PtO2 catalyst.
To reduce a nitro group to a primary amine but not reduce ketones, you can use Fe in HCl or H2/PtO2 catalyst.
More
VOTE
The reagent can reduce a nitro group to a primary amine but not reduce ketones, you can use sodium sulphide.
The reagent can reduce a nitro group to a primary amine but not reduce ketones, you can use sodium sulphide.
More
VOTE
One can use Fe in HCl to reduce Nitro group in presence of ketone oR H2/Pt
One can use Fe in HCl to reduce Nitro group in presence of ketone oR H2/Pt
More
VOTE