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Why can't dopamine cross the blood brain barrier but l-dopa can?
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Posted by
Marc Hellé
Why can't dopamine cross the blood brain barrier but l-dopa can?
Both L-Dopa and Dopamine are polar molecules and thus hydrophilic. They are solvable in water but not in lipids, so they are not able to cross the Blood-brain barrier on their own.
The difference is that L-Dopa has a transport protein (SLC7A5) that allows it to pass through the Blood-brain barrier, whereas dopamine doesn't.
Both L-Dopa and Dopamine are polar molecules and thus hydrophilic. They are solvable in water but not in lipids, so they are not able to cross the Blood-brain barrier on their own.
The difference is that L-Dopa has a transport protein (SLC7A5) that allows it to pass through the Blood-brain barrier, whereas dopamine doesn't.
Both L-Dopa and Dopamine are polar molecules and thus hydrophilic. They are solvable in water but not in lipids, so they are not able to cross the Blood-brain barrier on their own.
The difference is that L-Dopa has a transport protein (SLC7A5) that allows it to pass through the Blood-brain barrier, whereas dopamine doesn't.
Both L-Dopa and Dopamine are polar molecules and thus hydrophilic. They are solvable in water but not in lipids, so they are not able to cross the Blood-brain barrier on their own.
The difference is that L-Dopa has a transport protein (SLC7A5) that allows it to pass through the Blood-brain barrier, whereas dopamine doesn't.
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