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+ Stem cell culture
+ Stem cell biology
+ Tissue engineering
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Matas Vaitkevicius

How to achieve a monolayer from growing organoids?

Armando  Follow

Hi Myra,
I am currently having the exact problem you had. Please how did you finally resolved this issue?
Thanks

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Billy Chang  Follow

Hi Myra,
Could you specifiy what kind of organoids you cultivate? because i only know organoids as a 3D culture. but not monolayer, as they are derived from 3D embryoid bodies....
Thanks
Anja

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Chris Sherwood  Follow

Anja, thanks for the reply. Im currently culturing human intestinal organoids. 
Thanks Saleh, I will try that. :-)

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Alexandre Courvoisier  Follow

Myra Hosmillo

Dear Myra,

I am currently working on monolayer culture from organoids and make confluent layer. If you could provide me with your protocol, might be I can resolved this issue for you?@ Myra Hosmillo

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Christan Middleton  Follow

Hello
For primary organoid culture we used 1mg/ml collagenase type IA (Sigma) , try with this
Hope Help You
Good Luck
http://www.diss.fu-berlin.de/docs/servlets/MCRFileNodeServlet/FUDOCS_derivate_000000005333/srep12681.pdf

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Andy Heilveil  Follow
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Abid Hussain  Follow

 from PSC or from ASC? If ASC, there are at least 4 Publications using it: Etteyabi et al Science 2016 (human intestinal into 2D), VanDussen et al 2015 (human intestinal into 2D) Bartfeld et al Jove 2015 (human gastric into 2D), Schlaermann et al, Gut 2015 (human gastric organoids into 2D). Good luck

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