Amphetamine poisoning
Amphetamine (benzedrine) is a non-catecholamine sympathomimetic drug that excites α and β adrenergic nerve endings, stimulates the central nervous system, heart, and respiratory organs, and has the effects of increasing blood pressure, constricting peripheral blood vessels, exciting the heart, relaxing bronchial and intestinal muscles, dilating pupils, and constricting bladder sphincter. The therapeutic dose can reduce fatigue and produce a sense of self-euphoria. It is clinically used for narcolepsy, poisoning by anesthetics and other central depressants, and depression. This drug is rapidly absorbed after 1 to 2 hours of intestinal or parenteral administration. About 30% to 40% is destroyed in the liver by deamination, and the remaining unchanged drugs are mainly excreted in the urine. Acidic urine can promote its excretion. For those who are sensitive to this drug, only 2 mg can cause poisoning symptoms. The general toxic dose is 15 to 20 mg at a time, and 30 mg will cause severe reactions. The minimum lethal dose for adults is about 250 mg, and rapid intravenous injection of 120 mg can cause death. Long-term use can tolerate higher doses, and some patients have survived after taking 400-500 mg.