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Nucleoside Drugs


An antiproliferative 5-fluorouracil releasing compound

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1,2,4-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.1,2,4-Triazoles can be prepared using the Einhorn–Brunner reaction or the Pellizzari reaction.Unsubstituted 1,2,4-triazole can be prepared from thiosemicarbazide by acyation with formic acid and subsequent cyclization of 1-formyl-3-thiosemicarbazide into 1,2,4-triazole-3(5)-thiol; oxydation of thiol by nitric acid yelds 1,2,4-triazole.The ring structure appears in certain N-heterocyclic carbenes.

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Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively
Nucleoside drugs are an important class of drugs used clinically to treat viral infectious diseases, tumors, and AIDS. Nearly 50% of the currently used antiviral drugs are nucleoside drugs, and the antitumor drugs Cytarabine, Doxifluridine, etc. also belong to the nucleoside class. Nucleoside and deoxynucleoside series derivatives have a variety of biologically active substances, which can be used directly or indirectly as drugs, and play an extremely important role in the treatment of a variety of major diseases.
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