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Home > Biochemical Engineering > Nucleoside Drugs (Find 387 items)

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Nucleoside Drugs

Capecitabine

(154361-50-9)
An antiproliferative 5-fluorouracil releasing compound

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Cytidine

(65-46-3)
increases cell membrane phospholipids

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5-Aza-2'-deoxycytidine

(2353-33-5)
Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively

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5-Fluorouracil

(51-21-8)
5-Fluoro Uracil is an active metabolite of Doxifluridine(D556750).

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2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

(161599-46-8)
A metabolite of Capecitabine.

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1,2,4-Triazole

(288-88-0)
1,2,4-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole derivatives find use in a wide variety of applications, most notably as antifungals such as fluconazole and itraconazole.1,2,4-Triazoles can be prepared using the Einhorn–Brunner reaction or the Pellizzari reaction.Unsubstituted 1,2,4-triazole can be prepared from thiosemicarbazide by acyation with formic acid and subsequent cyclization of 1-formyl-3-thiosemicarbazide into 1,2,4-triazole-3(5)-thiol; oxydation of thiol by nitric acid yelds 1,2,4-triazole.The ring structure appears in certain N-heterocyclic carbenes.

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2,6-Dichloropurine

(5451-40-1)
2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.

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4-Chloropyrrolo[2,3-d]pyrimidine

(3680-69-1)
used in the manufacture of Tofacitinib citrate.

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6-Chloropurine

(87-42-3)
Used as an intermediate for purine products

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Cladribine

(4291-63-8)
It is a substituted purine nucleoside with antileukemic activity

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Nucleoside drugs are an important class of drugs used clinically to treat viral infectious diseases, tumors, and AIDS. Nearly 50% of the currently used antiviral drugs are nucleoside drugs, and the antitumor drugs Cytarabine, Doxifluridine, etc. also belong to the nucleoside class. Nucleoside and deoxynucleoside series derivatives have a variety of biologically active substances, which can be used directly or indirectly as drugs, and play an extremely important role in the treatment of a variety of major diseases.

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