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    Home > API > Drugs Influencing Immune Function (Find 13 items)

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    Drugs Influencing Immune Function

    Rapamycin

    (53123-88-9)
    Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.[Cayman Chemical]

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    Diacerein

    (13739-02-1)
    A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic

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    Melatonine

    (73-31-4)
    1. Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase
    2. Sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger
    3. Immunostimulant;Melatonin receptor ligand
    4. Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

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    Imiquimod

    (99011-02-6)
    raw material for Latamoxef, Cefminox, Ceftizoxime, Cefoxitin, Cefmetazole

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    Everolimus

    (159351-69-6)
    Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

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    Mizoribine

    (50924-49-7)
    Nucleoside antibiotic with cytotoxicand immunosuppressive activity

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    ISOPRINOSINE

    (36703-88-5)
    Isoprinosine

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    TNFR-Fc fusion protein

    (185243-69-0)
    Etanercept (Enbrel) is a tumor necrosis factor (TNF) inhibitor used for treating rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and plaque psoriasis.

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    Muromonab-CD3

    (140608-64-6)
    Monoclonal antibody (immunosuppressant).Muromonab-(CD3) alters the cell-mediated immune response by binding to the CD3 (cluster of differentiation antigen, T3) glycoprotein on T lymphocytes. It is used for the prevention of acute allograft rejection in kidney and hepatic transplants and as prophylaxis in cardiac transplantation. It is also used to deplete T cells in marrow from donors before bone marrow transplantation.

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    RAT IL-2

    (95568-40-4)
    It is used to treat AIDS and tumors, and has a certain effect on viral, bacterial, fungal or protozoan infections such as hepatitis, tuberculosis, and nodular leprosy. Adverse reactions and contraindications: fever, nausea, vomiting, fatigue and discomfort can be seen with systemic medication. Occasionally face redness, chills, diarrhea, edema and symptomatic hypertension.

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    There are two types of drugs that affect immune function: immunosuppressive drugs can suppress the immune response of those with excessive immune activity; immune-enhancing drugs can support the immune function of those with low immune function. There are five types of commonly used immunosuppressants: glucocorticoids, microbial metabolites, antimetabolites, polyclonal and monoclonal anti-lymphocyte antibodies, and alkylating agents. At present, commonly used immune-enhancing drugs are chemical synthetic drugs levamisole, isoprinosine, etc., human or animal immune products thymosin, transfer factor, interferon, interleukin, etc., BCG vaccines derived from microorganisms and other sources of biological polysaccharides, active ingredients of traditional Chinese medicine Wait. "Drugs Influencing Immune Function" on Echemi mainly supplies APIs for drugs that affect immune function.

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