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Drugs Influencing Immune Function


1. Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase
2. Sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger
3. Immunostimulant;Melatonin receptor ligand
4. Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

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Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM). It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.[Cayman Chemical]

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It is widely used in new liquid crystal polymers, high-strength fibers and engineering plastics with excellent performance; this product is an important inhibitor of osteoarthritis IL-1. Natural antioxidants, have the effects of delaying aging, enhancing immunity, clearing sub-health conditions, restoring physical fitness, improving energy and body immunity; an interleukin-1β inhibitor, a slow-acting anthraquinone compound.

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Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.


The main pharmacological effects of isopinosine are as follows: (1) Isopinosine can promote the proliferation of lymphocytes induced by phytohemagglutinin (PHA), concanavalin A (ConA), tetanus toxoid and influenza virus. (2) Enhance the delayed type allergic reaction caused by dinitrochlorobenzene, and restore the delayed type allergic reaction suppressed by cyclophosphamide to normal. (3) Restore the proliferative response of mouse spleen lymphocytes to ConA, which is inhibited by cyclophosphamide. (4) This product can also promote the production of interleukin 1 (IL-1), interleukin 2 (IL-2) and interferon, and enhance the activity of mononuclear macrophages and natural killer cells (NK). This product can also restore normal immune function due to aging, including decreased lymphocyte proliferation caused by aging, NK cytotoxicity, monocyte chemotaxis, and the number of plaque-forming cells. Normal or close to normal.


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raw material for Latamoxef, Cefminox, Ceftizoxime, Cefoxitin, Cefmetazole Anti-condyloma acuminata, immunomodulator

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TNFR-Fc fusion protein

Etanercept (Enbrel) is a tumor necrosis factor (TNF) inhibitor used for treating rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and plaque psoriasis.


It is used to treat AIDS and tumors, and has a certain effect on viral, bacterial, fungal or protozoan infections such as hepatitis, tuberculosis, and nodular leprosy. Adverse reactions and contraindications: fever, nausea, vomiting, fatigue and discomfort can be seen with systemic medication. Occasionally face redness, chills, diarrhea, edema and symptomatic hypertension.

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There are two types of drugs that affect immune function: immunosuppressive drugs can suppress the immune response of those with excessive immune activity; immune-enhancing drugs can support the immune function of those with low immune function. There are five types of commonly used immunosuppressants: glucocorticoids, microbial metabolites, antimetabolites, polyclonal and monoclonal anti-lymphocyte antibodies, and alkylating agents. At present, commonly used immune-enhancing drugs are chemical synthetic drugs levamisole, isoprinosine, etc., human or animal immune products thymosin, transfer factor, interferon, interleukin, etc., BCG vaccines derived from microorganisms and other sources of biological polysaccharides, active ingredients of traditional Chinese medicine Wait. "Drugs Influencing Immune Function" on Echemi mainly supplies APIs for drugs that affect immune function.
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