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Home > Biochemical Engineering > Inflammation Mediators (Find 130 items)

Inflammation Mediators

(+)-Cloprostenol

(54276-21-0)
(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

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2-AG

(53847-30-6)
2-Arachidonoylglycerol is a major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. It plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.

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Beraprost

(88430-50-6)
Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

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ETYA

(1191-85-1)
Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively)[1]. Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM[2].

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11-DEHYDRO THROMBOXANE B2

(67910-12-7)
A metabolite of Thromboxane that is an in vivo markers of oxidative stress and platelet activation. It is associated with adverse cardiovascular events in Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT).

CARBACYCLIN

(69552-46-1)
Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin. Carbaprostacyclin inhibits platelet aggregation with 10% of the molar potency exhibited by PGI2. The ED50 of carbaprostacyclin for the in vitro inhibition of ADP-induced platelet aggregation in human PRP is 47 nM. It was also shown to effect terminal differentiation of preadipose into adipose cells and enhance the expression of angiotensinogen and adipose fatty acid binding protein with an EC50 of about 0.5 μM.

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AA-5-HT

(187947-37-1)
Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC 50 values are 5.6 μ M and 37-40 nM for FAAH and TRPV1 respectively). Inactive at cPLA 2 , CB 1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

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Inflammatory mediators refer to chemically active substances that are produced and released by local tissues or plasma under the action of inflammatory factors, and participate in or cause inflammatory reactions, so they are also called chemical mediators. There are two types, exogenous (bacteria and their products) and endogenous, but mainly the latter. Endogenous can be divided into two categories: cell-derived and plasma-derived. "Cell-derived" include vasoactive amines, prostaglandins, leukotrienes, lysosomal components and lymphokines, etc. The inflammatory mediators produced by plasma include kinin system, complement system, coagulation system and fibrinolytic system.
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