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Biological Response Modifiers


Immunostimulant used in patients with cell-mediated immunodepression.

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An aminopeptidase inhibitor used in combination with chemotherapeutics for the maintenance and enhancement of complete remission of acute non-lymphocytic leukemia in adults.

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Used in combination with chemotherapy drugs in patients with gastrointestinal tumors, it can prolong survival time and prevent leukopenia or serum total protein reduction. It has a certain effect on chronic hepatitis B, can significantly improve the patient~"s symptoms, make the serum alanine aminotransferase normal or better, and adjust the patient~"s immune function. Note: Even anaphylactic shock, white blood cell and hemoglobin reduction symptoms may occur. Children and women of pregnancy and childbearing age should be used with caution.

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Aristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids

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Polyinosinic acid

For the treatment of viral hepatitis, herpes zoster, herpes simplex keratitis, herpes stomatitis, epidemic hemorrhagic fever and other diseases

Polyinosinic acid-polycytidylic acid

It has the role of immune adjuvant, which can stimulate the reticuloendothelial system, enhance the phagocytic function of phagocytes, enhance the formation of antibodies, and stimulate allograft reactions and delayed allergic reactions. It has broad-spectrum antiviral and antitumor effects. It is mainly used clinically to prevent or treat viral infections, to treat herpes zoster, herpes keratitis, and viral hepatitis. Adjuvant treatment of tumors. Adverse reactions mainly include transient hypothermia, and individual cases have high fever above 38℃, which usually subsides within 1-2 days. If the fever does not disappear within 2 days, the drug should be stopped immediately. See also fatigue, dry mouth, dizziness, nausea, etc.

Polyinosinic acid-polycytidylic acid s...

TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.


PHA is a mitogen. In vitro, it can stimulate the transformation of small lymphocytes into immunologically active lymphocytes and promote their division. The transformed lymphocytes can secrete various lymphokines. 1. The transformation effect of PHA on peripheral blood lymphocytes. Peripheral blood lymphocytes are cultured with PHA in vitro to transform small lymphocytes into lymphoblasts. 2. PHA stimulates lymphocyte mitosis. 3. PHA can enhance the rosette rate of lymphocytes and can be used to judge the body~"s cellular immune function. 4. PHA can promote the phagocytosis of peritoneal macrophages. 5. PHA can induce the production of cell migration inhibitory factors. 6. PHA can be used to study the Asia-Pacific group of lymphocytes.
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Biological response modifiers (BRM), also known as biological regulators, is a new term for immunotherapeutics. Any substance or method that directly or indirectly enhances the body's anti-tumor effect through the immune system and has a therapeutic effect on the tumor can be called a biological response modifier. Biological regulators have multiple functions and uses. It can enhance the body's anti-tumor function, induce tumor cells to differentiate and mature into normal cells; reduce the immunosuppressive effect, enhance the body's tolerance to toxic substances and directly enhance the body's defense capabilities, promote early recovery of the disease; Radiation therapy and surgical treatment have a curative effect on tumors and reduce their side effects.
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