Neurotrophic keratitis is a degenerative disease in which the corneal epithelium is healed poorly. It is characterized by loss of corneal sensation, which leads to corneal stromal dissolution and perforation. There are many reasons for corneal hypoesthesia, and everything from the trigeminal nerve nucleus to the corneal nerve endings may be affected. Among them, herpes virus infection and damage to the ophthalmic branch of the trigeminal nerve are the most common causes. If the cause is not found, the possibility of abuse of anesthetic eye drops should be considered. When corneal sensation is destroyed, the nutritional effect of cholinergic sensory fibers on the corneal epithelium disappears, and the resulting decrease in epithelial growth rate affects wound healing, and may cause epithelial defects even in the absence of trauma.