Here we mainly introduce two commonly used pesticides: organophosphorus and organotin. Organophosphorus pesticides are the most widely used agricultural insecticides. There are many types, strong insecticidal power, and a wide insecticidal spectrum. They have been widely used in agricultural production, but they are highly toxic to humans and animals. The main cause of poisoning caused by organophosphorus is failure to comply with operating procedures during use, or imperfect protective equipment during production and use. The main route of invasion into the human body is through the respiratory tract and skin, and those who enter the digestive tract are mostly accidental ingestion or suicide. After entering the body, organophosphorus inhibits the activity of cholinesterase in the body. It causes excessive excitement of cholinergic nerves, leading to dysfunction of the nervous system. Psychiatric symptoms and neurological symptoms and signs appear.