Severe infections, especially Gram-negative bacterial infections, can often cause septic shock. Septic shock, also known as septic shock, refers to sepsis syndrome accompanied by shock caused by microorganisms and their toxins. Microorganisms and their toxins, cell wall products, etc. in the infection focus invade the blood circulation, activate various cells and body fluid systems of the host, produce cytokines and endogenous mediators, act on various organs and systems of the body, affect their perfusion, and lead to tissue cell ischemia and hypoxia, metabolic disorders, functional disorders, and even multiple organ failure. This critical syndrome is septic shock. Therefore, septic shock is the result of the interaction between microbial factors and the body's defense mechanism. The virulence and quantity of microorganisms and the body's internal environment and response are important factors that determine the development of septic shock.